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Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: A collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials
Department of Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.
Department of Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden.
Department of Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden.
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2012 (English)In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 98, no 3, 207-213 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To perform a patient-pooled analysis of a routine invasive versus a selective invasive strategy in elderly patients with non-ST segment elevation acute coronary syndrome. Methods: A meta-analysis was performed of patientpooled data from the FRISC IIeICTUSeRITA-3 (FIR) studies. (Un)adjusted HRs were calculated by Cox regression, with adjustments for variables associated with age and outcomes. The main outcome was 5-year cardiovascular death or myocardial infarction (MI) following routine invasive versus selective invasive management. Results: Regarding the 5-year composite of cardiovascular death or MI, the routine invasive strategy was associated with a lower hazard in patients aged 65-74 years (HR 0.72, 95% CI 0.58 to 0.90) and those aged ≥75 years (HR 0.71, 95% CI 0.55 to 0.91), but not in those aged less than65 years (HR 1.11, 95% CI 0.90 to 1.38), p=0.001 for interaction between treatment strategy and age. The interaction was driven by an excess of early MIs in patients less than65 years of age; there was no heterogeneity between age groups concerning cardiovascular death. The benefits were smaller for women than for men (p=0.009 for interaction). After adjustment for other clinical risk factors the HRs remained similar. Conclusion: The current analysis of the FIR dataset shows that the long-term benefit of the routine invasive strategy over the selective invasive strategy is attenuated in younger patients aged less than65 years and in women by the increased risk of early events which seem to have no consequences for long-term cardiovascular mortality. No other clinical risk factors were able to identify patients with differential responses to a routine invasive strategy. Trial registration: (ICTUS), (RITA-3).

Place, publisher, year, edition, pages
BMJ Publishing Group , 2012. Vol. 98, no 3, 207-213 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-74116DOI: 10.1136/heartjnl-2011-300453OAI: diva2:480560
Available from: 2012-01-19 Created: 2012-01-19 Last updated: 2013-09-11

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Swahn, Eva
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