Mortality Statistics Studies of Multiple Sclerosis and Amyotrophic Lateral Sclerosis in Sweden
2012 (English)In: Neuroepidemiology, ISSN 0251-5350, E-ISSN 1423-0208, Vol. 38, no 4, 245-249 p.Article in journal (Refereed) Published
Background: Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are chronic neurologic diseases where distinct explanations of the pathogenesis are lacking. Two large Swedish register studies have rather unexpectedly detected a correlation between MS and ALS.
The aim of this study was to investigate if an association between ALS and MS could be demonstrated as has been shown earlier.
Material and methods: Data on mortality from ALS and MS, 1990-2010 were collected from the Swedish national statistics office. In all there were 5,696 deaths due to ALS and 3,941 deaths due to MS. Age- and sex-adjusted mortality rates were calculated.
Results: There was no correlation between the mortality rates of ALS and MS in the 21 counties of Sweden for the period 1990 to 2010 (Spearman’s rho = - 0.052; p = 0.822; n = 21).
The national mean mortality rate for ALS throughout the period of 1990 to 2010 was 2.98 per 100 000 person-years (95% CI 2.87 – 3.08). For MS the national mean mortality rate was 2.04 per 100 000 person-years (95% CI 1.95 – 2.12). Both ALS and MS mortality showed significant variation between the counties. Conclusion: This study did not confirm the previously shown association between MS and ALS in Sweden.
Place, publisher, year, edition, pages
S. Karger, 2012. Vol. 38, no 4, 245-249 p.
Amyotrophic lateral sclerosis; multiple sclerosis; mortality; correlation, epidemiology, genetics
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-74175DOI: 10.1159/000338031ISI: 000305659200008OAI: oai:DiVA.org:liu-74175DiVA: diva2:480854