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Mortality Statistics Studies of Multiple Sclerosis and Amyotrophic Lateral Sclerosis in Sweden
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences.
Dept of Public Health and Primary Health Care, University of Bergen, BERGEN, Norway.
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
2012 (English)In: Neuroepidemiology, ISSN 0251-5350, E-ISSN 1423-0208, Vol. 38, no 4, 245-249 p.Article in journal (Refereed) Published
Abstract [en]

Background: Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are chronic neurologic diseases where distinct explanations of the pathogenesis are lacking. Two large Swedish register studies have rather unexpectedly detected a correlation between MS and ALS.

The aim of this study was to investigate if an association between ALS and MS could be demonstrated as has been shown earlier.

Material and methods: Data on mortality from ALS and MS, 1990-2010 were collected from the Swedish national statistics office. In all there were 5,696 deaths due to ALS and 3,941 deaths due to MS. Age- and sex-adjusted mortality rates were calculated.

Results: There was no correlation between the mortality rates of ALS and MS in the 21 counties of Sweden for the period 1990 to 2010 (Spearman’s rho = - 0.052; p = 0.822; n = 21).

The national mean mortality rate for ALS throughout the period of 1990 to 2010 was 2.98 per 100 000 person-years (95% CI 2.87 – 3.08). For MS the national mean mortality rate was 2.04 per 100 000 person-years (95% CI 1.95 – 2.12). Both ALS and MS mortality showed significant variation between the counties. Conclusion: This study did not confirm the previously shown association between MS and ALS in Sweden.

Place, publisher, year, edition, pages
S. Karger, 2012. Vol. 38, no 4, 245-249 p.
Keyword [en]
Amyotrophic lateral sclerosis; multiple sclerosis; mortality; correlation, epidemiology, genetics
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-74175DOI: 10.1159/000338031ISI: 000305659200008OAI: oai:DiVA.org:liu-74175DiVA: diva2:480854
Available from: 2012-01-20 Created: 2012-01-20 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Epidemiological Studies of Multiple Sclerosis in Sweden with focus on the County of Värmland
Open this publication in new window or tab >>Epidemiological Studies of Multiple Sclerosis in Sweden with focus on the County of Värmland
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of this thesis was to study the frequency of MS in the suggested high-risk area of Värmland county by investigating the current prevalence and analyzing the development over time; secondly to investigate some aetiological factors – the pattern of industry, both in relation to MS in Värmland and in the whole country, and also to examine the possible relation between the distribution of MS and ALS, as it has previously shown a positive correlation in two studies; finally to analyze the women-to-men ratio of MS in Sweden because of international reports of an increasing ratio.

Clinical data was collected from hospitals and other health care units in the county of Värmland, to calculate the prevalence ratio. The prevalence was 170.07 per 100,000 population on the prevalence day, 31 December 2002. The incidence rates analysed during ten years was 6.46 per 100,000 personyears (1991-1995) and 6.39 (1996-2000).

The ecological study used data from the beginning of the 20th century on industries in Värmland and in all Sweden, which were correlated with the two MS prevalence studies (1925-1934 and 2002), and the mortality study on the time period 1952-1990. There was a statistical significant association between large sawmills and the prevalence 1925-1934 (p = 0.022). For all Sweden, wood-pulp factories and papermills correlated significantly with MS mortality 1952-1990 (p = <0.05).

Collected data from Causes of death Register and from the Total Population Register were used when analysing mortality from ALS and MS. The previously shown correlation between ALS and MS mortality distribution in the Swedish counties was not confirmed in this study. However, the mean MS mortality rate was still highest in the county in Värmland. The mean MS mortality rates for whole Sweden was increased from 1.65 per 100,000 person-years (1952-1992) to 2.04 (1990-2010).

For analysing sex ratio in MS, data from the Swedish Multiple Sclerosis Register and data from Total Population Register of the Swedish Statistics Office were used. These data was analysed by birth day cohort and by year of onset. The sex ratios in Sweden showed a stable women-to-men ratio.

These investigations give indication that Värmland is a high-risk region of multiple sclerosis, and particularly the municipality of Säffle.

We conclude that Värmland is a suitable area for continued epidemiological studies with both an environment and genetic focus.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2012. 52 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1286
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-74177 (URN)978-91-7519-990-0 (ISBN)
Public defence
2012-02-17, Sal Linden, Hälsouniversitetet, Campus US, Linköpings universitet, Linköping, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2012-01-20 Created: 2012-01-20 Last updated: 2012-02-15Bibliographically approved

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Boström, IngerLandtblom, Anne-Marie

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