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N-acetyl cysteine improves glycogenesis after segmental liver ischemia and reperfusion injury in pigs
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Östergötland.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Östergötland.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Östergötland.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Östergötland.
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2012 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 47, no 2, 225-236 p.Article in journal (Refereed) Published
Abstract [en]

Abstract Objective. N-acetylcysteine (NAC) is an antioxidative molecule known to protect liver tissue from oxygen radical species generated during ischemia and reperfusion (IR). Nutritional and toxicology studies have shown that NAC also improves glucose metabolism and glycogen stores. We hypothesized that NAC improves glycogenesis and that impaired glycogenesis is a key element in IR injury. Material and Methods. In an experimental model, 80 min of segmental liver ischemia was induced in 16 pigs and the reperfusion was followed for 360 min. Eight animals received NAC 150 mg/kg as a bolus injection followed by an infusion of NAC 50 mg/kg/h intravenously. Results. AST and leukocyte density were lower in the NAC-treated animals, unrelated to the glutathione levels or apoptosis. Glycogen stores returned to a higher degree in the NAC-treated animals and microdialysis revealed lower levels of lactate during the reperfusion phase. Nitrite/Nitrate levels in the NAC group were lower in both serum and microdialysates, indicating that NAC scavenges radical nitrosative species. Conclusions. NAC treatment improves glycogenesis after liver IR injury and reduces the level of intraparenchymal lactate during reperfusion, possibly due to the scavenging of radical nitrosative species.

Place, publisher, year, edition, pages
Informa Healthcare, 2012. Vol. 47, no 2, 225-236 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-74184DOI: 10.3109/00365521.2011.643480OAI: oai:DiVA.org:liu-74184DiVA: diva2:481144
Available from: 2012-01-20 Created: 2012-01-20 Last updated: 2017-12-08

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Winbladh, AndersBjörnsson, BergthorTrulsson, LenaBojmar, LindaSundqvist, TommySandström, Per

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Winbladh, AndersBjörnsson, BergthorTrulsson, LenaBojmar, LindaSundqvist, TommySandström, Per
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SurgeryFaculty of Health SciencesDepartment of Surgery in ÖstergötlandDepartment of Clinical and Experimental MedicineMedical Microbiology
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Scandinavian Journal of Gastroenterology
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