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Relationships between platelets and inflammatory markers in rheumatoid arthritis
Linköping University, Department of Social and Welfare Studies, Health, Activity, Care. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in the East of Östergötland.
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in the East of Östergötland, Department of Internal Medicine VHN.
2004 (English)In: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 343, no 1-2, 237-240 p.Article in journal (Refereed) Published
Abstract [en]

Aim of the study: To investigate platelets and different inflammatory markers in conjunction with a substantial inflammatory reaction. We used individuals with active rheumatoid arthritis (RA) as an experimental cohort. Methods: We selected 16 patients with active RA having at least one affected joint. On day 1, platelet and neutrophil counts together with C-reactive protein (CRP) were determined. We further analysed platelet volume (MPV) and plasma levels of thrombopoietin (TPO), P-selectin, myeloperoxidase and interleukin 6 (IL-6). After 2 years when all patients failed to show any swollen joints all analyses were repeated. Results and conclusions: As expected platelet count, CRP and IL-6 were elevated in active RA. The measures correlated with each other thus reflecting the same characteristic of the inflammatory response. The neutrophil count, MPV and myeloperoxidase also mirror disease activity. They failed to correlate with other activity markers thus providing unique information. MPV and myeloperoxidase on day 1 correlated with recovery values. Therefore, they could be suitable to use when following the inflammatory reaction over a long period of time.

Place, publisher, year, edition, pages
Elsevier, 2004. Vol. 343, no 1-2, 237-240 p.
Keyword [en]
Interleukin 6; Myeloperoxidase; Platelets; Rheumatoid arthritis; Soluble P-selectin; Thrombopoietin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-74254DOI: 10.1016/j.cccn.2003.12.030OAI: oai:DiVA.org:liu-74254DiVA: diva2:481789
Available from: 2012-01-22 Created: 2012-01-22 Last updated: 2017-12-08

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Milovanovic, MichaNillsson, EthelJäremo, Petter

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Health, Activity, CareFaculty of Health SciencesRheumatologyLocal Health Care Services in the East of ÖstergötlandCardiologyDepartment of Internal Medicine VHN
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Clinica Chimica Acta
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