Inverse relationships between coronary blood flow obstruction and platelet reactivity in stable angina pectoris
2005 (English)In: Platelets, ISSN 0953-7104, E-ISSN 1369-1635, Vol. 16, no 3-4, 211-213 p.Article in journal (Refereed) Published
This study investigates relationships between platelet reactivity and coronary blood flow obstruction in stable angina pectoris. Consented were 36 patients with single-vessel disease. The subjects were divided into two groups. One group (n = 14) had less severe (< = 80%) and the second group (n = 22) had severe coronary flow impairment (90%). Before elective coronary angiography platelet in vitro reactivity in venous whole blood was determined using a flow cytometry technique. A thrombin-receptor activating peptide (TRAP-6) (0.77 and 0.06 g/l) and ADP (8.5 and 1.7 µmol/l) were used to activate platelets. The number of fibrinogen positive cells (%) i.e., activated platelets after stimulation was employed as experimental parameter. Less severe flow obstruction was associated with more reactive platelets. When stimulating with 0.77 g/l TRAP-6 the number of activated platelets was 64 ± 15 (SD)%. The corresponding value for the group with severe flow obstruction was 40 ± 17(SD)%. The difference is significant (P < 0.001). 0.06 g/l TRAP-6 yielded similar results (P < 0.01). Also when using 8.5 µmol/l ADP to challenge platelets less severe flow obstruction was associated with enhanced reactivity (P < 0.01). 1.7 µmol/l ADP generated comparable results (P < 0.05). Thus, in stable angina pectoris coronary flow obstruction is inversely related to platelet reactivity.
Place, publisher, year, edition, pages
Informa Healthcare, 2005. Vol. 16, no 3-4, 211-213 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-74255DOI: 10.1080/09537100400016813OAI: oai:DiVA.org:liu-74255DiVA: diva2:481791