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Inverse relationships between coronary blood flow obstruction and platelet reactivity in stable angina pectoris
Linköping University, Department of Social and Welfare Studies, Health, Activity, Care. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL.
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL.
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in the East of Östergötland, Department of Internal Medicine VHN.
2005 (English)In: Platelets, ISSN 0953-7104, E-ISSN 1369-1635, Vol. 16, no 3-4, 211-213 p.Article in journal (Refereed) Published
Abstract [en]

This study investigates relationships between platelet reactivity and coronary blood flow obstruction in stable angina pectoris. Consented were 36 patients with single-vessel disease. The subjects were divided into two groups. One group (n = 14) had less severe (< = 80%) and the second group (n = 22) had severe coronary flow impairment (90%). Before elective coronary angiography platelet in vitro reactivity in venous whole blood was determined using a flow cytometry technique. A thrombin-receptor activating peptide (TRAP-6) (0.77 and 0.06 g/l) and ADP (8.5 and 1.7 µmol/l) were used to activate platelets. The number of fibrinogen positive cells (%) i.e., activated platelets after stimulation was employed as experimental parameter. Less severe flow obstruction was associated with more reactive platelets. When stimulating with 0.77 g/l TRAP-6 the number of activated platelets was 64 ± 15 (SD)%. The corresponding value for the group with severe flow obstruction was 40 ± 17(SD)%. The difference is significant (P < 0.001). 0.06 g/l TRAP-6 yielded similar results (P < 0.01). Also when using 8.5 µmol/l ADP to challenge platelets less severe flow obstruction was associated with enhanced reactivity (P < 0.01). 1.7 µmol/l ADP generated comparable results (P < 0.05). Thus, in stable angina pectoris coronary flow obstruction is inversely related to platelet reactivity.

Place, publisher, year, edition, pages
Informa Healthcare, 2005. Vol. 16, no 3-4, 211-213 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-74255DOI: 10.1080/09537100400016813OAI: oai:DiVA.org:liu-74255DiVA: diva2:481791
Available from: 2012-01-22 Created: 2012-01-22 Last updated: 2017-12-08

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Milovanovic, MichaFransson, Sven GöranRichter, ArinaJäremo, Petter

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Health, Activity, CareFaculty of Health SciencesDepartment of Medical and Health SciencesDepartment of Cardiology UHLCardiologyDepartment of Internal Medicine VHN
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