liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Development of Organ-Specific Progenitor Cell Cultures as Efficacy Test Platforms for Electron-Spun Fibre Meshes in Regenerative Medicine Applications
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 80 credits / 120 HE creditsStudent thesis
Abstract [en]

The nervous and cardiovascular system plays the most complex and vital role in all organisms. Any damage or injury to these essential organs in our body results in long term irreversible impairment or death. The main goal of the regenerative medicine is to repair or recreate tissues using stem cells to restore the vital function of the targeted organ. Along with organ specific stem/progenitor cells, non-toxic, biodegradable synthetic polymers are also needed for an effective reparative therapy. The effect of PCL materials and surface modified (PEDOT coated) PCL materials of different topology with neural progenitor cells as test platforms are evaluated for cytotoxicity and neuron differentiation. The stem cells from heart are isolated and characterized as cardiac stem cells by Fluorescence activated cell sorting through specific antigen expression. The cardiac stem cells are used to establish effective proliferation and differentiation system. Hence, developing cardiac and neural progenitor cell cultures as an efficacy test platforms for biomaterials of different diameter and orientation benefits respective tissue engineering with proper restoration of function. Further, the nerve and cardiac tissue rejuvenation would serve as a regenerative therapy for numerous neurodegenerative disorders and cardiovascular disorders like myocardial infarction respectively.

Place, publisher, year, edition, pages
2011. , 31 p.
Keyword [en]
Cardiovascular, regenerative, progenitor, topology, PEDOT coated PCL, cytotoxicity, Fluoroscence, proliferation, differentiation, neurodegenerative, myocardial infarction
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-74232ISRN: LiTH-IFM-A-EX--11/2448--SEOAI: diva2:482185
Subject / course
Technical Physics
2011-12-15, ODEN, B21, Linkoping University, Linkoping, 08:15 (English)
Available from: 2012-02-08 Created: 2012-01-21 Last updated: 2012-02-08Bibliographically approved

Open Access in DiVA

fulltext(1938 kB)384 downloads
File information
File name FULLTEXT01.pdfFile size 1938 kBChecksum SHA-512
Type fulltextMimetype application/pdf

By organisation
Department of Physics, Chemistry and BiologyThe Institute of Technology
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
Total: 384 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 97 hits
ReferencesLink to record
Permanent link

Direct link