Implications of genomic instability in the diagnosis and treatment of breast cancer
2011 (English)In: Expert Review of Molecular Diagnostics, ISSN 1473-7159, E-ISSN 1744-8352, Vol. 11, no 4, 445-453 p.Article in journal (Refereed) Published
Tumorigenesis is a multistep process resulting from DNA mutations observed at the DNA sequence and chromosome level as well as epigenetic changes, which affect expression of oncogenes and tumor suppressor genes. Breast cancer is a very heterogeneous disease that manifests in various histological and clinical types. Defects in the biological action of the genome driven by various alterations, such as point mutations and chromosomal rearrangements, lead to the collapse of genome integrity, uncontrolled cell proliferation and failure in apoptotic cell death. Detailed profiling of breast cancer-associated genomic alterations is indispensable for the design of individualized anticancer therapy, by suggesting diagnostic and prognostic criteria as well as the outcome of applied treatment. Among various directions of cancer research, identification of genomic alterations in breast cancer and their translation into clinical applications is at the forefront.
Place, publisher, year, edition, pages
Expert Reviews , 2011. Vol. 11, no 4, 445-453 p.
breast cancer; chromosomal aberrations; diagnosis; genomic instability; prognosis; treatment
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-74304DOI: 10.1586/erm.11.21OAI: oai:DiVA.org:liu-74304DiVA: diva2:482593