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Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis
Lund University Hospital.
Max Planck Institute of Biochemistry, Martinsried, Germany .
Babraham Institute, Cambridge, UK .
University of Lund.
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2003 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 198, no 10, 1495-1506 p.Article in journal (Refereed) Published
Abstract [en]

Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7Ralpha, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7Ralpha and FL completely lack visible LNs, conventional IgM(+) B cells, IgA(+) plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- X IL-7Ralpha(-/-) BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7Ralpha(-/-) mice, FL-/- X IL-7Ralpha(-/-) mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7Ralpha are indispensable for fetal and adult B cell development.

Place, publisher, year, edition, pages
Rockefeller University Press , 2003. Vol. 198, no 10, 1495-1506 p.
Keyword [en]
lymphopoiesis; IL-7 receptor; Flt3 ligand; Pax5; B1 cells
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-74461DOI: 10.1084/jem.20031152ISI: 000186845600005OAI: diva2:484768
Available from: 2012-01-27 Created: 2012-01-27 Last updated: 2012-02-06

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Sigvardsson, Mikael
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