liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
The roles of transcription factors in B lymphocyte commitment, development, and transformation
Lund University.
Lund University.
2004 (English)In: Journal of Leukocyte Biology, ISSN 0741-5400, E-ISSN 1938-3673, Vol. 75, no 6, 973-981 p.Article, review/survey (Refereed) Published
Abstract [en]

Studies of normal blood cell development and malignant transformation of hematopoietic cells have shown that the correctly regulated expression of stage- and lineage-specific genes is a key issue in hematopoiesis. Experiments in transgenic mice have defined a number of transcription factors such as SCL/Tal, core-binding factor/acute myeloid leukemia, and c-myb, all crucial for the establishment of definitive hematopoiesis and development of A blood cell lineages. Other regulators such as IKAROS, E47/E2A, early B cell factor, Sox-4, and B cell-specific activator protein (Pax-5) appear crucial, more or less selectively, for B lymphopoiesis, allowing for detailed analysis of the development of this lineage. In addition, several of these transcription factors are found translocated in human tumors, often resulting in aberrant gene expression or production of modified proteins. This article concerns the role of transcription factors in B lymphoid development with special focus on lineage initiation and commitment events but also to some extent on the roles of transcription factors in human B lymphoid malignancies.

Place, publisher, year, edition, pages
Society for Leukocyte Biology , 2004. Vol. 75, no 6, 973-981 p.
Keyword [en]
hematopoietic cells; early B cell factor; B cell specific activator protein; E2A; B lineage malignancies
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-74457DOI: 10.1189/jlb.1103554ISI: 000221918800004OAI: diva2:484781
Available from: 2012-01-27 Created: 2012-01-27 Last updated: 2012-02-06

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sigvardsson, Mikael
In the same journal
Journal of Leukocyte Biology
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 6 hits
ReferencesLink to record
Permanent link

Direct link