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Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
Institute for Stem Cell Research, National Research Center for Environment and Health, Neuherberg/Munich.
Institute for Stem Cell Research, National Research Center for Environment and Health, Neuherberg/Munich.
Institute for Stem Cell Research, National Research Center for Environment and Health, Neuherberg/Munich.
Institute for Stem Cell Research, National Research Center for Environment and Health, Neuherberg/Munich.
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2007 (English)In: Molecular and Cellular Neuroscience, ISSN 1044-7431, E-ISSN 1095-9327, Vol. 34, no 1, 99-119 p.Article, review/survey (Refereed) Published
Abstract [en]

Appropriate neurogenesis and patterning of the forebrain requires the transcription factor Pax6, yet it is largely unknown how Pax6 exerts its effects at the molecular level. To characterize Pax6-mediated regulation of gene expression during murine forebrain neurogenesis, we performed microarray analysis with tissue from the dorsal Pax6-dependent telencephalon and the ventral Pax6-negative telencephalon at the onset of neurogenesis (E12) and at mid-neurogenesis (E15) in wild-type and Pax6-deficient mutant littermates. In the Pax6-deficient cortex the expression levels of various transcription factors involved in neurogenesis (like Satb2, Nfia, AP-2 gamma, NeuroD6, Ngn2, Tbr2, Bhlhb5) and the retinoic acid signalling molecule Rlbp1 were reduced. Regulation by Pax6 could be confirmed upon electroporation of a Pax6- and a dominant-negative Pax6-containing vector into embryonic cortex. Taken together, our data reveal novel insights into the molecular pathways regulated by Pax6 during cortical neurogenesis. Most intriguingly, this analysis revealed time- and region-specific differences in Pax6-mediated transcription, explaining the specific function of Pax6 at early and later stages of neurogenesis.

Place, publisher, year, edition, pages
Elsevier , 2007. Vol. 34, no 1, 99-119 p.
Keyword [en]
Pax6; cortex; ganglionic eminence; small eye; telencephalon; microarray; electroporation; neurogenesis; retinoic acid signalling
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-74446DOI: 10.1016/j.mcn.2006.10.008ISI: 000243598200011OAI: oai:DiVA.org:liu-74446DiVA: diva2:484822
Available from: 2012-01-27 Created: 2012-01-27 Last updated: 2017-12-08

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Sigvardsson, Mikael

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