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Nocturnal temperature controller laminar airflow for treating atopic asthma: a randomised controlled trial
Imperial College London.
Karolinska Institutet, Stockholm.
Karolinska Institutet, Stockholm.
Lund University Hospital.
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2012 (English)In: Thorax, ISSN 0040-6376, E-ISSN 1468-3296, Vol. 67, no 3, 215-221 p.Article in journal (Refereed) Published
Abstract [en]

   Objective To determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma. <br> <br>Design Randomised, double-blind, placebo-controlled, parallel-group trial. <br> <br>Setting Nineteen European asthma clinics. <br> <br>Participants 312 patients aged 7-70 with inadequately controlled persistent atopic asthma. <br> <br>Main outcome measure Proportion of patients with an increase of &gt;= 0.5 points in asthma quality of life score after 1 year of treatment. <br> <br>Results TLA devices were successfully installed in the bedrooms of 282 (90%) patients included in the primary efficacy analysis. There was a difference in treatment response rate between active (143 of 189, 76%) and placebo (56 of 92, 61%) groups, difference 14.8% (95% CI 3.1 to 26.5, p=0.02).(3) In patients aged &gt;= 12, on whom the study was powered, the difference in response rate was similar-active 106 of 143 (74%), placebo 42 of 70 (60%), difference 14.1% (0.6 to 27.7, p=0.059). There was a difference between groups in fractional exhaled nitric oxide change of -7.1 ppb (-13.6 to -0.7, p=0.03). Active treatment was associated with less increase in cat-specific IgE than placebo. There was no difference in adverse event rates between treatment groups. <br> <br>Conclusion Inhalant exposure reduction with TLA improves quality of life, airway inflammation and systemic allergy in patients with persistent atopic asthma. TLA may be a treatment option for patients with inadequately controlled persistent atopic asthma.

Place, publisher, year, edition, pages
BMJ Publishing Group , 2012. Vol. 67, no 3, 215-221 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-74496DOI: 10.1136/thoraxjnl-2011-200665ISI: 000300625300008OAI: diva2:486046

funding agencies|Airsonett AB||National Institute for Health Research||National Institute for Health Research Biomedical Research Centre||MRC||Asthma UK Centre in Allergic Mechanisms of Asthma||

Available from: 2012-01-30 Created: 2012-01-30 Last updated: 2014-09-10

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Zetterström, Olle
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