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Is adolescent perutssis vaccination prefrable to natural booster infections?
Swedish Institute for Communicable Disease Control, Stockholm.
Linköping University, Department of Clinical and Experimental Medicine, Allergy Centre. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Allergy Centre UHL.
Swedish Institute for Communicable Disease Control, Stockholm.
2011 (English)In: Expert Review of Clinical Pharmacology, ISSN 1751-2433 (Print); 1751-2441 (Online), Vol. 4, no 6, 705-711 p.Article in journal (Refereed) Published
Abstract [en]

Pertussis is still poorly controlled in both adolescents and adults. As a result, an adolescent pertussis booster vaccine dose has already been implemented or decided on in many countries. The reasons for this have been twofold: a worrying increase of infections in the target group of adolescents and a wish to prevent serious pertussis disease among young yet unvaccinated, and partly vaccinated, infants. Currently, it is still too early to evaluate the effect of the late booster on the circulation of Bordetella pertussis owing to the lack of relevant follow-up data. A universal adolescent booster vaccination will reduce the incidence of pertussis in the target group but the duration of immunity is uncertain. It is an open question as to what extent boosters should be offered to older age groups or if natural infections would be preferable. On the one hand, circulating B. pertussis may be hazardous to the youngest unvaccinated infants. On the other hand, subclinical natural boosters might be beneficial to population immunity. As the duration of immunity is shorter after vaccination than after natural infections, an unwanted consequence of adolescent boosters might shift the infection peak to older child-bearing adults. It is therefore recommended that recurrent serosurveys are used to follow the influence of vaccination on the antigenic pressure, as well as the duration of protective immunity. For this purpose, standardization of symptoms and laboratory criteria used for notification, as well as the methodology for seroepidemiology, must be established. Adverse reactions after adolescent vaccination and outbreaks owing to new B. pertussis variants must also be carefully monitored. In this article, we have used Swedish surveillance data and the results from Swedish seroepidemiology to illustrate these problem areas.

Place, publisher, year, edition, pages
2011. Vol. 4, no 6, 705-711 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-74497DOI: 10.1586/ecp.11.55OAI: diva2:486061
Available from: 2012-01-30 Created: 2012-01-30 Last updated: 2012-12-20

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