Mechanisms of general anesthetic action: Focus on the cellular network
2011 (English)In: TRANSLATIONAL NEUROSCIENCE, ISSN 2081-3856, Vol. 2, no 2, 168-175 p.Article in journal (Refereed) Published
The discovery of general anesthetics had a tremendous impact on development of surgery and medicine in general, during the last century. Despite the widespread use of general anesthetics, the mechanisms by which they produce their effects in the central nervous system are still poorly understood. Over the past decade, several new findings have contributed significantly to a better understanding of general anesthetic mechanisms. The current review summarizes recent data on different anesthetic neuronal targets that might be involved in the mechanism of action of general anesthetics, giving special attention to the importance of binding pockets for anesthetics within transmembrane receptors and cellular signaling leading to morphological changes of neuronal cells. Several lines of evidence suggest that disruption in brain network connectivity is important for anaesthesia-induced loss of consciousness and this is discussed in relation to morphological changes.
Place, publisher, year, edition, pages
VERSITA, SOLIPSKA 14A-1, 02-482 WARSAW, POLAND , 2011. Vol. 2, no 2, 168-175 p.
Theories of anesthetic action, Signaling cascade, GABA(A) receptor, NMDA receptors, Brain connectivity
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-74656DOI: 10.2478/s13380-011-0022-5ISI: 000298886600010OAI: oai:DiVA.org:liu-74656DiVA: diva2:489459