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Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis
Falun General Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-3993-9985
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
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2012 (English)In: Clinical & Developmental Immunology, ISSN 1740-2522, E-ISSN 1740-2530, Vol. 2012, no 294587Article in journal (Refereed) Published
Abstract [en]

Why some individuals develop clinical manifestations in Lyme borreliosis (LB) while others remain asymptomatic is largely unknown. Therefore, we wanted to investigate adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed Borrelia-antibody-positive asymptomatic children (n = 20), children with previous clinical LB (n = 24), and controls (n = 20). Blood samples were analyzed for Borrelia-specific interferon (IFN)-gamma, interleukin (IL)-4, and IL-17 secretion by ELISPOT and Borrelia-induced IL-1 beta, IL-6, IL-10, IL-12(p70), and tumor necrosis factor (TNF) secretion by Luminex. We found no significant differences in cytokine secretion between groups, but a tendency towards an increased spontaneous secretion of IL-6 was found among children with previous clinical LB. In conclusion, the adaptive or innate immune responsiveness to Borrelia burgdorferi sensu lato was similar in Borrelia-exposed asymptomatic children and children with previous clinical LB. Thus, the immunological mechanisms of importance for eradicating the spirochete effectively without developing clinical manifestations of LB remain unknown.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation , 2012. Vol. 2012, no 294587
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-74647DOI: 10.1155/2012/294587ISI: 000298814000001OAI: oai:DiVA.org:liu-74647DiVA: diva2:489753
Note
Funding Agencies|Research Council in Southeast Sweden (FORSS)||County Council in Ostergotland||Swedish Child Diabetes Foundation||Juvenile Diabetes Research Foundations||Holmia Foundation||Center of Clinical Research in Dalarna (CKF)||Available from: 2012-02-03 Created: 2012-02-03 Last updated: 2017-12-08

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Ekerfelt, ChristinaJenmalm, MariaForsberg, PiaLudvigsson, JohnnyErnerudh, Jan

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Ekerfelt, ChristinaJenmalm, MariaForsberg, PiaLudvigsson, JohnnyErnerudh, Jan
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Clinical ImmunologyFaculty of Health SciencesPediatricsInfectious DiseasesDepartment of Infectious Diseases in ÖstergötlandDepartment of Paediatrics in LinköpingDepartment of Clinical Immunology and Transfusion Medicine
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