liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Risk and Predictive Factors for Liver Cancer: Analysis of Data from a Cohort Study
Linköping University, Department of Computer and Information Science, Statistics. Linköping University, The Institute of Technology.
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

The association between the risk of liver cancer and blood chemistry was investigated in a cohort study with 95,150 men and women from two counties in Sweden. In 1963-65, blood tests and physical measurements were undertaken. All individuals were then followed up until 2007, and a total of 312 were diagnosed with liver cancer. Using survival analysis and logistic regression, significant risk factors were identified. Stepwise Cox proportional hazards regression applied to a main effect model revealed that Glutamic Pyruvate Transaminase (GPT) and Thymol Turbidity (TYM) were the most significant risk factors (p<0.0001), followed by Protein-Bound Hexoses (HEX)  (p=0.002), sex (p=0.02), and Serum Iron (p= 0.03). Increasing the level of GPT expressed in U/L from normal (<21) to slightly elevated (21, 31) or substantially elevated (>31) raised the hazard of experiencing liver cancer by a factor of 1.45 and 4.09, respectively. In addition, GPT was found to be the most significant risk factor in almost all age groups among both men and women. However, there was no evidence that elevated GPT levels within the normal range (<21), influenced the risk of liver cancer. Additional subgroup analyses revealed that TYM was highly significant within the group with normal GPT, and a high level of HEX (≥134 mg/dl) increased the hazard 1.55 times in comparison with the lowest HEX group (<115 mg/dl). BMI was significant only in the male subgroup  (p<0.01) and, in the obesity group, the hazard of experiencing liver cancer was 1.99 times higher than in the normal BMI group. A significant three-way interaction between GPT, BMI and gender was present (p=0.05) with a robust significant two-way interaction between GPT and BMI (p<0.01) in the male subgroup.

Place, publisher, year, edition, pages
2011. , p. 57
Keywords [en]
Liver cancer, risk factors, survival analysis, logistic regression
National Category
Probability Theory and Statistics
Identifiers
URN: urn:nbn:se:liu:diva-75038ISRN: LIU-IDA/STAT-A--11/004--SEOAI: oai:DiVA.org:liu-75038DiVA, id: diva2:502733
Subject / course
Program in Statistics and Data Analysis
Presentation
2011-06-10, 11:30 (English)
Uppsok
Physics, Chemistry, Mathematics
Supervisors
Examiners
Available from: 2012-03-12 Created: 2012-02-14 Last updated: 2012-03-12Bibliographically approved

Open Access in DiVA

fulltext(1628 kB)650 downloads
File information
File name FULLTEXT01.pdfFile size 1628 kBChecksum SHA-512
62116f7f6b213bdd6a78f190386a7de8f8e72f358ddf9aa1c38323f5336bb574388bad377f48f9de86daaf757044f32ef729a9ede5c5362afc5c6cbc1e897f32
Type fulltextMimetype application/pdf

By organisation
StatisticsThe Institute of Technology
Probability Theory and Statistics

Search outside of DiVA

GoogleGoogle Scholar
Total: 650 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 296 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf