liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Hyperspectral Image Analysis Algorithm for Characterizing Human Tissue
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

AbstractIn the field of Biomedical Optics measurement of tissue optical properties, like absorption, scattering, and reduced scattering coefficient, has gained importance for therapeutic and diagnostic applications. Accuracy in determining the optical properties is of vital importance to quantitatively determine chromophores in tissue.There are different techniques used to quantify tissue chromophores. Reflectance spectroscopy is one of the most common methods to rapidly and accurately characterize the blood amount and oxygen saturation in the microcirculation. With a hyper spectral imaging (HSI) device it is possible to capture images with spectral information that depends both on tissue absorption and scattering. To analyze this data software that accounts for both absorption and scattering event needs to be developed.In this thesis work an HSI algorithm, capable of assessing tissue oxygenation while accounting for both tissue absorption and scattering, is developed. The complete imaging system comprises: a light source, a liquid crystal tunable filter (LCTF), a camera lens, a CCD camera, control units and power supply for light source and filter, and a computer.This work also presents a Graphic processing Unit (GPU) implementation of the developed HSI algorithm, which is found computationally demanding. It is found that the GPU implementation outperforms the Matlab “lsqnonneg” function by the order of 5-7X.At the end, the HSI system and the developed algorithm is evaluated in two experiments. In the first experiment the concentration of chromophores is assessed while occluding the finger tip. In the second experiment the skin is provoked by UV light while checking for Erythema development by analyzing the oxyhemoglobin image at different point of time. In this experiment the melanin concentration change is also checked at different point of time from exposure.It is found that the result matches the theory in the time dependent change of oxyhemoglobin and deoxyhemoglobin. However, the result of melanin does not correspond to the theoretically expected result.

Place, publisher, year, edition, pages
2011. , 61 p.
Keyword [en]
Hyper spectral image analysis, GPU programming, Bio optics, CUDA programming, Göran Salerud, Marcus Larsson, Yonas Kassaw, Yonas K. Wondim, Non negative Least square analysis, tissue oxygenation, melanin concentration, Ethiopia, Debub University, Linköping University, Ethiopians in Sweden
National Category
Medical Image Processing
URN: urn:nbn:se:liu:diva-75156ISRN: LiTH-IMT/MASTER-EX--11/009--SEOAI: diva2:504083
Subject / course
Masterprogram Biomedical Engineering (BME)
2011-11-29, IMT1, Linköping, 11:00 (English)
Available from: 2012-02-20 Created: 2012-02-17 Last updated: 2012-06-12Bibliographically approved

Open Access in DiVA

Yonas_Kassaw(2142 kB)1677 downloads
File information
File name FULLTEXT01.pdfFile size 2142 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Wondim, Yonas kassaw
By organisation
Biomedical InstrumentationThe Institute of Technology
Medical Image Processing

Search outside of DiVA

GoogleGoogle Scholar
Total: 1677 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 543 hits
ReferencesLink to record
Permanent link

Direct link