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Renal preservation in children with neurogenic bladder-sphincter dysfunction followed in a national program
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
2012 (English)In: Journal of Pediatric Urology, ISSN 1477-5131, E-ISSN 1873-4898, Vol. 8, no 2, 187-193 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Neurogenic bladder-sphincter dysfunction (NBSD) constitutes the major reason for morbidity in children with spina bifida. The aim of this study was to identify risk factors for renal damage in children with NBSD followed according to the Swedish national guidelines. MATERIALS AND METHODS: Records and cystometries from 6 to 16 years (median 11) follow up of 41 consecutive children born 1993-2003 with NBSD were evaluated. The children were divided into a high pressure group (baseline pressure above 30 cmH(2)O at maximal clean intermittent catheterization volume in at least two cystometries) and a low pressure group. Most children (34/41) were followed from birth. RESULTS: Although renal scarring on DMSA-scintigraphy was found in 5/41 children, all but one had normal renal function. Two already had renal scars on entering the follow-up program at age 2.5 and 3 years. Renal scarring was more frequent in the high pressure group (P < 0.01). Most children with renal scars (4/5) had a combination of low compliant bladder and insufficient compliance with treatment and follow up. CONCLUSION: High baseline pressure is confirmed as a risk factor that, in combination with complex social issues, creates a demanding situation for families and professionals. A structured early follow up with treatment compliance effectively prevents renal damage.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 8, no 2, 187-193 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-75251DOI: 10.1016/j.jpurol.2011.02.003ISI: 000300988900016PubMedID: 21411372OAI: oai:DiVA.org:liu-75251DiVA: diva2:505370
Note

funding agencies|Medical Research Council of Southeast Sweden||County Council of Ostergotland||Swedish Inheritance Fund||

Available from: 2012-02-23 Created: 2012-02-23 Last updated: 2017-12-07Bibliographically approved

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Wide, PeterGlad Mattsson, GunillaMattsson, Sven

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Wide, PeterGlad Mattsson, GunillaMattsson, Sven
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