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C-peptide in the classification of diabetes in children and adolescents
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
University of Lund Hospital.
Queen Silvia Childrens Hospital.
University Hospital MAS.
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2012 (English)In: Pediatric Diabetes, ISSN 1399-543X, E-ISSN 1399-5448, Vol. 13, no 1, 45-50 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. less thanbrgreater than less thanbrgreater thanMethods: A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up. C-peptide was determined in a validated and controlled time-resolved fluoroimmunoassay. less thanbrgreater than less thanbrgreater thanResults: The clinical classification of diabetes, before any information on human leukocyte antigen, islet autoantibodies, or C-peptide was received, was type 1 diabetes (T1D) in 93%, type 2 diabetes (T2D) in 1.9%, maturity onset diabetes of the young (MODY) in 0.8%, secondary diabetes (0.6%), while 3.3% could not be classified. In a random, non-fasting serum sample at diagnosis, 56% of the patients had a C-peptide value andgt; 0.2 nmol/L. Children classified as T2D had the highest mean C-peptide (1.83 + 1.23 nmol/L) followed by MODY (1.04 +/- 0.71 nmol/L) and T1D (0.28 +/- 0.25 nmol/L). Only 1/1037 children who had C-peptide andlt; 0.2 nmol/L at diagnosis was classified with a type of diabetes other than T1D. Predictive value of C-peptide andgt; 1.0 nmol/L for the classification of either T2D or MODY was 0.46 [confidence interval 0.37-0.58]. less thanbrgreater than less thanbrgreater thanConclusions: More than half of children with newly diagnosed diabetes have clinically important residual beta-cell function. As the clinical diagnosis is not always straightforward, a random C-peptide taken at diagnosis may help to classify diabetes. There is an obvious use for C-peptide determinations to evaluate beta-cell function in children with diabetes.

Place, publisher, year, edition, pages
John Wiley and Sons , 2012. Vol. 13, no 1, 45-50 p.
Keyword [en]
beta-cell function, children, C-peptide, type 1 diabetes, type 2 diabetes
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-75276DOI: 10.1111/j.1399-5448.2011.00807.xISI: 000299549900008OAI: diva2:505944
Funding Agencies|Barndiabetesfonden (the Swedish Child Diabetes Foundation)||Available from: 2012-02-27 Created: 2012-02-24 Last updated: 2012-02-27

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Ludvigsson, JohnnySamuelsson, Ulf
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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Pediatric Diabetes
Medical and Health Sciences

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