liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells
New York University School of Medicine.
New York University School of Medicine.
University of Maryland.
New York University School of Medicine.
2012 (English)In: Cell Host and Microbe, ISSN 1931-3128, Vol. 11, no 1, 81-90 p.Article in journal (Refereed) Published
Abstract [en]

Mycobacterium tuberculosis promotes its replication by inhibiting the apoptosis of infected macrophages. A proapoptotic M. tuberculosis mutant lacking nuoG, a subunit of the type I NADH dehydrogenase complex, exhibits attenuated growth in vivo, indicating that this virulence mechanism is essential. We show that M. tuberculosis also suppresses neutrophil apoptosis. Compared to wild-type, the nuoG mutant spread to a larger number of lung phagocytic cells. Consistent with the shorter lifespan of infected neutrophils, infection with the nuoG mutant resulted in fewer bacteria per infected neutrophil, accelerated bacterial acquisition by dendritic cells, earlier trafficking of these dendritic cells to lymph nodes, and faster CD4 T cell priming. Neutrophil depletion abrogated accelerated CD4 T cell priming by the nuoG mutant, suggesting that inhibiting neutrophil apoptosis delays adaptive immunity in tuberculosis. Thus, pathogen modulation of apoptosis is beneficial at multiple levels, and enhancing phagocyte apoptosis promotes CD4 as well as CD8 T cell responses.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 11, no 1, 81-90 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-75365DOI: 10.1016/j.chom.2011.11.012PubMedID: 22264515OAI: diva2:506247
Available from: 2012-02-28 Created: 2012-02-28 Last updated: 2012-03-05

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Blomgran, Robert
In the same journal
Cell Host and Microbe
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 45 hits
ReferencesLink to record
Permanent link

Direct link