Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls
2012 (English)In: The Aging Male, ISSN 1368-5538, E-ISSN 1473-0790, Vol. 15, no 1, 59-62 p.Article in journal (Refereed) Published
Background: Age related bone loss is widely accepted as related to decreased serum levels of circulating sex hormones. Epidemiological data also show distal radius fractures in men to be a sensitive marker of bone fragility. The aim of this study was to assess if men with a history of distal radius fracture have lower bone mass density (BMD), lower free androgen index (FAI), lower total testosterone (T) and lower bio-available testosterone (Bio-T) than healthy age-matched controls. Patients and methods: A case-control study is based on consecutive cases treated for low energy distal radius fracture at our department and age-matched controls. Thirty-nine men treated between 1997-2004 and 45 age-matched controls underwent calcaneal bone density measurements (t-score) and analyses of T, Bio-T and serum hormone binding globulin (SHBG). Results: The fracture group had lower BMD (p andlt; 0.01) and lower FAI (p = 0.01). Linear regression analysis showed a correlation between Bio-T and t-scores (p = 0.03). Using analysis of covariance, a significant difference with lower Bio-T in the fracture group was shown. Conclusion: Bio-T seems to correlate with BMD in elderly men and may serve as a marker for increased fracture risk in this patient group.
Place, publisher, year, edition, pages
Informa Healthcare , 2012. Vol. 15, no 1, 59-62 p.
Bone mineral density, male, fractures, osteoporosis, testosterone
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-75464DOI: 10.3109/13685538.2011.593659ISI: 000299840800010OAI: oai:DiVA.org:liu-75464DiVA: diva2:507096
Funding Agencies|County Council of Ostergotland||2012-03-022012-03-022012-03-21