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Olfactory sensitivity for "green odors" (Aliphatic C6 Alcohols and C6 aldehydes) - A comparative study in male CD-1 mice (Mus musculus) and female spides monkeys (Ateles geoffroyi)
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, The Institute of Technology.
Instituto de Neuro-Etologia, Universidad Veracruzana, 91000 Xalapa, Veracruz, Mexico.
Linköping University, Department of Physics, Chemistry and Biology, Zoology. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-5583-2697
2012 (English)In: Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, E-ISSN 1873-5177, Vol. 101, no 3, 450-457 p.Article in journal (Refereed) Published
Abstract [en]

Using a conditioning paradigm, the olfactory sensitivity of six male CD-1 mice for “green odors”, a group of eightstructurally related aliphatic C6 alcohols and aldehydes known to exert anxiolytic and stress-reducing effects,was investigated. With all eight stimuli, the animals discriminated concentrations!0.03 ppm(parts per million)from the solvent, and with three of the eight stimuli the best-scoring animals were even able to detect concen-trations !0.03 ppb (parts per billion). Three female spider monkeys tested in parallel were found to detect thesame eight stimuli at concentrations b1 ppm, and with six of the eight stimuli the best-scoring animals detectedconcentrations !0.1 ppm. Analysis of odor structure–activity relationships showed that in both species the typeof functional group attached to the aliphatic C6 backbone of the odorant molecules systematically affected theirolfactory sensitivity whereas the presence/absence of a double bond did not. In the mice, but not in the spidermonkeys, the position of a double bond and the cis/trans-configuration of the odorant molecules also had a sys-tematic effect on detectability of the “green odors”. A comparison of the detection thresholds between the twospecies tested here and those obtained in human subjects suggests that the number of functional olfactory recep-tor genes is a poor predictor of a species' olfactory sensitivity for “green odors”.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 101, no 3, 450-457 p.
Keyword [en]
Olfactory detection thresholds, Green odors, Mouse, Spider monkey, Odor structure-activity relationships
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-75542DOI: 10.1016/j.pbb.2012.02.013ISI: 000303182100018OAI: oai:DiVA.org:liu-75542DiVA: diva2:508097
Note

funding agencies|Consejo Nacional de Ciencia y Tecnologia (CONACYT Mexico)| J-51435-IV |

Available from: 2012-03-07 Created: 2012-03-07 Last updated: 2017-12-07

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Løtvedt, Pia KatrineLaska, Matthias

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