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Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk
Queens University of Belfast.
Glostrup University Hospital.
Medical University of Vienna.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
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2012 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 61, no 3, 702-707 p.Article in journal (Refereed) Published
Abstract [en]

Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals andlt;3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals andlt;3 years.

Place, publisher, year, edition, pages
American Diabetes Association , 2012. Vol. 61, no 3, 702-707 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-75715DOI: 10.2337/db11-1000ISI: 000300800600021OAI: diva2:508782
Available from: 2012-03-09 Created: 2012-03-09 Last updated: 2014-10-29

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Ludvigsson, Johnny
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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