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Susceptibility of Children to Sapovirus Infections, Nicaragua, 2005–2006
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Department of Microbiology, University of León, UNAN-León, Nicaragua.
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
University of Gothenburg, Göteborg, Sweden.
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2012 (English)In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 18, no 11, 1875-1878 p.Article in journal (Refereed) Published
Abstract [en]

We describe the genetic diversity of sapovirus (SaV) in children in Nicaragua and investigate the role of host genetic factors and susceptibility to SaV infections. Our results indicate that neither ABO blood group, Lewis phenotype, nor secretor status affects susceptibility to SaV infection in Nicaragua.

Place, publisher, year, edition, pages
Atlanta, GA, USA: U.S. Department of Health and Human Services * Centers for Disease Control and Prevention , 2012. Vol. 18, no 11, 1875-1878 p.
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-76034DOI: 10.3201/eid1811.111581ISI: 000328172600023PubMedID: 23092588OAI: oai:DiVA.org:liu-76034DiVA: diva2:511710
Note

On the day of the defence day the status of this article was

Manuscript

Available from: 2012-03-23 Created: 2012-03-23 Last updated: 2017-12-07Bibliographically approved
In thesis
1. Human Caliciviruses: a study of viral evolution, host genetics and disease susceptibility
Open this publication in new window or tab >>Human Caliciviruses: a study of viral evolution, host genetics and disease susceptibility
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The viruses described in this thesis are the norovirus and sapoviruses, which belong to the family of human caliciviruses and are known to cause gastroenteritis in humans. Gastroenteritis has emerged as a global health problem and is based on the large number of infected considered as one of the most common diseases today. According to estimates of the World Health Organization (WHO), gastroenteritis causes over five times more pediatric deaths compared to pediatric deaths caused by HIV/AIDS worldwide. Norovirus, the cause of the famous “winter vomiting disease”, is alone responsible for more than 200 000 deaths each year in children less than 5 years of age.

The mechanism for emergence and evolution of new human calicivirus strains, as well as protective immunity in the human population is poorly understood. The main focus for this thesis was to elucidate the possible correlation between human calicivirus evolution, host genetics and disease susceptibility. One of the main findings presented in this thesis is the documentation of in vivo capsid gene evolution and quasispecies dynamics during chronic NoV GI.3 infection (Paper 1). In paper II, we reported that the G428A nonsense mutation in the FUT2 gene provides strong but not absolute protection against symptomatic GII.4 NoV infection. In my last two papers (Paper III and IV), we were the first to investigate host genetic susceptibility factors during authentic SaV infection.

To summarize, the results presented in this thesis show that the success of human calicivirus infection probably is determined by a delicate interplay between virus evolution and susceptibility of the host, both genetically and immunologically.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2012. 77 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1303
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-76036 (URN)978-91-7519-922-1 (ISBN)
Public defence
2012-04-12, Eken, Hälsouniversitetet, Campus US, Linköpings univeristet, Linköping, 09:00 (Swedish)
Opponent
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Available from: 2012-03-23 Created: 2012-03-23 Last updated: 2012-05-07Bibliographically approved

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Carlsson, BeatriceNordgren, JohanSvensson, Lennart

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