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Growth hormone does not stimulate early healing in rat tendons
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
2012 (English)In: International Journal of Sports Medicine, ISSN 0172-4622, E-ISSN 1439-3964, Vol. 33, no 3, 240-243 p.Article in journal (Refereed) Published
Abstract [en]

Growth Hormone stimulates bone growth and fracture repair. It acts mainly by increasing the systemic levels of IGF-1. Local treatment with IGF-1 appears to stimulate tendon healing. We therefore hypothesized that systemic treatment with Growth Hormone would also stimulate tendon healing. Rat Achilles tendons were transected and left to heal. 4 groups were studied. Intramuscular injections of botulinum toxin A (Botox) were used to reduce loading in 2 groups. The animals were randomized to twice daily injections of Growth Hormone (n=2×10) or saline (n=2×10), and killed after 10 days. Healing was assessed by mechanical testing. Muscle paralysis induced by Botox reduced the strength of the healing tendon by two thirds. Growth Hormone increased femoral and tibial length in the unloaded, and femoral and tibial weight in the loaded group. Body weight and muscle weight were increased in both. In contrast, there was no increase in the strength of the healing tendons, regardless of mechanical loading status. An increase in peak force of the loaded healing tendons by more than 5% could be excluded with 95% confidence. In spite of its stimulatory effects on other tissues, Growth Hormone did not appear to stimulate tendon or tendon repair.

Place, publisher, year, edition, pages
Stuttgart: Georg Thieme Verlag KG, 2012. Vol. 33, no 3, 240-243 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-76085DOI: 10.1055/s-0031-1291324ISI: 000301005800012PubMedID: 22318558OAI: oai:DiVA.org:liu-76085DiVA: diva2:512145
Note
funding agencies|Swedish Research council| 2009-6725 |Swedish National Center for Research in Sports||Available from: 2012-03-26 Created: 2012-03-26 Last updated: 2017-12-07

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Andersson, ThereseEliasson, PernillaAspenberg, Per

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