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Is vulnerability for carotid plaque rupture related to intrinsic Fe (III) distribution
Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-2167-2450
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2012 (English)Conference paper, Published paper (Other academic)
Abstract [en]

Atherosclerotic plaques vulnerable for rupture are characterised by e.g., a large lipid pole, a high concentration of inflammatory cells and a thin fibrous cap. Recent research has showed that vulnerable plaques are structurally weaker and therefore more likely to rupture in response to physical forces; possible due to high local concentrations of macrophages and reactive oxygen species (ROS).  It is well known that redox active iron catalyses production of ROS and that the presence of Fe(III) is linked to ROS production. The aim of this study was to investigate the distribution of Fe(III) in carotid plaques.

Place, publisher, year, edition, pages
2012.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-76101OAI: oai:DiVA.org:liu-76101DiVA: diva2:512298
Conference
XIV Svenska Kardiovaskulära Vårmötet, 25-27 April, Stockholm 2012
Available from: 2012-03-27 Created: 2012-03-27 Last updated: 2013-09-04

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Gustafsson, HåkanEngström, MariaZachrisson, Helene

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Gustafsson, HåkanEngström, MariaZachrisson, Helene
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Center for Medical Image Science and Visualization, CMIVRadiologyFaculty of Health SciencesClinical PhysiologyDepartment of Physics, Chemistry and BiologyThe Institute of TechnologyDepartment of Clinical and Experimental MedicineDepartment of Clinical Physiology UHL
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