Central pulse pressure elevation is common in patients with type 2 diabetes and office normotension, and is associated with markers of atherosclerosis
(English)Manuscript (preprint) (Other academic)
The aim of this study was to describe the prevalence of elevated central pulsepressure (CPP) in patients with type 2 diabetes and office normotension, and to investigatewhether elevated CPP was associated with markers of atherosclerosis in these patients. Wedetermined office and central blood pressure, carotid intima-media thickness (IMT) and aorticpulse wave velocity (PWV) in 167 patients with type 2 diabetes and office normotension(<130/80 mmHg). Patients with office normotension and CPP ≥50 mmHg (n=32) hadsignificantly higher carotid IMT (0.76±0.2 mm vs 0.71±0.1 mm, p=0.041) and aortic PWV(11.0±2.5 m/s vs 9.5±1.8 m/s, p<0.01) than patients with office normotension and CPP <50mmHg (n=135). We conclude that almost one in five patients with type 2 diabetes and officenormotension had elevated CPP, and that this was associated with markers of both structuraland functional atherosclerosis.
Type 2 diabetes, central pulse pressure, hypertension, pulse wave velocity
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-76136OAI: oai:DiVA.org:liu-76136DiVA: diva2:512649