Ambulatory systolic blood pressure predicts left ventricular mass in type 2 diabetes, independently of central systolic blood pressure
2012 (English)In: Blood Pressure Monitoring, ISSN 1359-5237, E-ISSN 1473-5725, Vol. 17, no 4, 139-144 p.Article in journal (Refereed) Published
Objectives: Both ambulatory and central blood pressures have been reported to correlate more closely than office blood pressure with left ventricular mass index (LVMI). The aim of this study was to test whether ambulatory systolic blood pressure (SBP) predicts LVMI independently of central SBP in patients with type 2 diabetes.
Methods: We determined office, ambulatory and central blood pressures and performed echocardiography in 460 patients with type 2 diabetes, who participated in the CARDIPP (Cardiovascular Risk factors in Patients with Diabetes – a Prospective study in Primary care) study (ClinicalTrials.gov number NCT 01049737).
Results: In separate multivariable regression models, both 24-hour ambulatory SBP, ambulatory day-time SBP, and ambulatory night-time SBP were significantly associated with LVMI, independently of central SBP, age, sex, BMI, ambulatory 24-hour heart rate, duration of known diabetes and presence or absence of any antihypertensive medications (r = 0.19, 0.17 and 0.18, respectively, P <0.01). All ambulatory SBP parameters, but not central SBP, were significantly associated with LVMI independently of office SBP.
Conclusions: Ambulatory SBP predicted LVMI independently of central SBP in patients with type 2 diabetes. The use of ambulatory blood pressure measurements may be encouraged as a tool for refined risk stratification of patients with type 2 diabetes.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2012. Vol. 17, no 4, 139-144 p.
ambulatory blood pressure, central blood pressure, hypertension, left ventricular hypertrophy, target organ damage, type 2 diabetes
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-76137DOI: 10.1097/MBP.0b013e328355fdfbISI: 000306330300001OAI: oai:DiVA.org:liu-76137DiVA: diva2:512655