The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
2011 (English)In: Clinical & Developmental Immunology, ISSN 1740-2522, E-ISSN 1740-2530, Vol. 2011, no 212810Article in journal (Refereed) Published
Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression. The present study aimed to investigate the role of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDAC) regarding expression of inflammatory factors and infiltration of immune cells and their impact on the clinical outcome. The PDAC tissues examined expressed significantly increased levels of immunomodulatory and chemotactic factors (IL-6, TGF beta, IDO, COX-2, CCL2, and CCL20) and immune cell-specific markers corresponding to macrophages, myeloid, and plasmacytoid dendritic cells (DCs) as compared to controls. Furthermore, short-time survivors had the lowest levels of DC markers. Immunostainings indicated that the different immune cells and inflammatory factors are mainly localized to the desmoplastic stroma. Therapies modulating the inflammatory tumor microenvironment to promote the attraction of DCs and differentiation of monocytes into functional DCs might improve the survival of PDAC patients.
Place, publisher, year, edition, pages
Hindawi Publishing Corporation , 2011. Vol. 2011, no 212810
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-76217DOI: 10.1155/2011/212810ISI: 000298696600001OAI: oai:DiVA.org:liu-76217DiVA: diva2:513031
Funding Agencies|Swedish Research Council|AI52731|Swedish International Development Cooperation Agency (SIDA)||VINN-MER (Vinnova)||Medical Research Council of Southeast Sweden||Swedish Society of Medicine||Foundation for Clinical Cancer Research in Jonkoping, Sweden||2012-03-302012-03-302012-05-09