liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cardiovascular risk factors related to the PPARγ Pro12Ala polymorphism in patients with type 2 diabetes are gender dependent
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.ORCID iD: 0000-0002-9095-403X
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Show others and affiliations
2012 (English)In: Blood Pressure, ISSN 0803-7051, E-ISSN 1651-1999, Vol. 21, no 2, 122-127 p.Article in journal (Refereed) Published
Abstract [en]

The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial. We studied 173 women and 309 men in the observational CARDIPP trial in which determination of left ventricular mass, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) were performed. Blood pressures were measured with 24-h ambulatory technique (ABP). Heterozygotes and homozygotes of Ala were defined as Ala in the analyses. Men with Ala-isoform displayed higher waist circumference (Ala: 107 ± 14 cm, Pro: 104 ± 11 cm, p = 0.045) and body weight (Ala: 95.7 ± 18 kg, Pro: 91.6 ± 14 kg, p = 0.042) than Pro-homozygotes. Men with ALA-isoform also showed higher systolic ABP levels (Ala: 134 ± 15 mmHg, Pro: 130 ± 14 mmHg, p = 0.004), whereas left ventricular mass index, IMT and PWV were unrelated to isoforms. In contrast, carotid–radial PWV was lower in women with the Ala-isoform (Ala: 7.9 ± 1.0 m/s, Pro: 8.5 ± 1.3 m/s, p = 0.01) and levels of apolipoprotein A1 were higher (Ala: 1.43 ± 0.27 g/l, Pro: 1.35 ± 0.17 g/l, p = 0.03). In conclusion, we found that men with type 2 diabetes having the Ala-isoform of PPARγ Pro12Ala had an unfavorable cardiovascular risk profile, whereas women with this isoform had lower carotid–radial PWV and higher apolipoprotein A1 levels suggesting a beneficial prognosis. These differences according to gender of the ALA isoform in type 2 diabetes deserve further attention.

Place, publisher, year, edition, pages
Informa Healthcare, 2012. Vol. 21, no 2, 122-127 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-76235DOI: 10.3109/08037051.2011.623349ISI: 000302022100009PubMedID: 22017455OAI: oai:DiVA.org:liu-76235DiVA: diva2:513076
Note

Funding agencies|Medical Research Council of Southeast Sweden||Center for Medical Image Science and Visualization (CMIV)||Faculty of Linkoping University||Swedish Heart-Lung Foundation||Medical Research council| 12661 |County Council of Ostergotland||Diabetes Research Centre||Futurum||GE Healthcare||

Available from: 2012-03-30 Created: 2012-03-30 Last updated: 2017-12-07Bibliographically approved

Open Access in DiVA

fulltext(401 kB)290 downloads
File information
File name FULLTEXT01.pdfFile size 401 kBChecksum SHA-512
60d9981d2851ff633c5e2427c18f890ceba0da9f1b7a30c080795150b6000de00886b75a6779926df737742dee1a1a6160ac0b58fcb0dcc8c8cb59b25c24c36a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Franck, NiclasLänne, TosteÅstrand, OlofEngvall, JanLindström, TorbjönÖstgren, Carl JohanNyström, Fredrik

Search in DiVA

By author/editor
Franck, NiclasLänne, TosteÅstrand, OlofEngvall, JanLindström, TorbjönÖstgren, Carl JohanNyström, Fredrik
By organisation
Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Thoracic and Vascular SurgeryDepartment of Clinical Physiology in LinköpingDepartment of EndocrinologyGeneral PracticePrimary Health Care in Motala
In the same journal
Blood Pressure
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 290 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 217 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf