Cytokine mapping in cerebrospinal fluid and blood in multiple sclerosis patients without oligoclonal bands
2012 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 18, no 5, 669-673 p.Article in journal (Refereed) Published
Objective: Since there are clinical and genetic differences between MS patients with intrathecal oligoclonal bands (OCB+ ) in the cerebrospinal fluid (CSF) compared with those without (OCB-), the aim was to find out if OCB- patients showed a different pattern of cytokine immune activation compared with OCB+ patients. Methods: The study included 25 MS patients (10 OCB- and 15 OCB+ ) and 13 controls. A panel of cytokines was measured; IL-1β, IL-6, IL-8/CXCL8, IL-10, TNF and GM-CSF in serum, CSF and in supernatants from polyclonally stimulated blood mononuclear cells, where also levels of IL-12p40, IL-13, IL-15, IL-17 and IFN-γ were measured. The concentrations of soluble (s) VCAM-1 and sCD14 were measured in serum and CSF. Results: In general, there were no extensive differences in cytokine concentrations between the OCB- and OCB+ groups. Conclusion: OCB- MS patients do not seem to constitute a separate entity concerning inflammatory parameters measured as cytokine concentrations in CSF and blood.
Place, publisher, year, edition, pages
2012. Vol. 18, no 5, 669-673 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-75970DOI: 10.1177/1352458511424903ISI: 000303319000107PubMedID: 21965416OAI: oai:DiVA.org:liu-75970DiVA: diva2:513164
funding agencies|Swedish Association of Neurologically Disabled||County Council of Ostergotland||University Hospital of Linkoping||2012-03-302012-03-202012-05-30