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Cytokine mapping in cerebrospinal fluid and blood in multiple sclerosis patients without oligoclonal bands
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.
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2012 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 18, no 5, 669-673 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Since there are clinical and genetic differences between MS patients with intrathecal oligoclonal bands (OCB+ ) in the cerebrospinal fluid (CSF) compared with those without (OCB-), the aim was to find out if OCB- patients showed a different pattern of cytokine immune activation compared with OCB+ patients. Methods: The study included 25 MS patients (10 OCB- and 15 OCB+ ) and 13 controls. A panel of cytokines was measured; IL-1β, IL-6, IL-8/CXCL8, IL-10, TNF and GM-CSF in serum, CSF and in supernatants from polyclonally stimulated blood mononuclear cells, where also levels of IL-12p40, IL-13, IL-15, IL-17 and IFN-γ were measured. The concentrations of soluble (s) VCAM-1 and sCD14 were measured in serum and CSF. Results: In general, there were no extensive differences in cytokine concentrations between the OCB- and OCB+ groups. Conclusion: OCB- MS patients do not seem to constitute a separate entity concerning inflammatory parameters measured as cytokine concentrations in CSF and blood.

Place, publisher, year, edition, pages
2012. Vol. 18, no 5, 669-673 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-75970DOI: 10.1177/1352458511424903ISI: 000303319000107PubMedID: 21965416OAI: oai:DiVA.org:liu-75970DiVA: diva2:513164
Note
funding agencies|Swedish Association of Neurologically Disabled||County Council of Ostergotland||University Hospital of Linkoping||Available from: 2012-03-30 Created: 2012-03-20 Last updated: 2017-12-07

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Vrethem, MagnusKvarnström, MariaCassel, PetraLandtblom, Anne-MarieErnerudh, Jan

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Vrethem, MagnusKvarnström, MariaCassel, PetraLandtblom, Anne-MarieErnerudh, Jan
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NeurologyFaculty of Health SciencesDepartment of NeurologyClinical ImmunologyDepartment of Medical SpecialistDepartment of Clinical Immunology and Transfusion Medicine
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Multiple Sclerosis
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