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Lower risk of stent thrombosis and restenosis with unrestricted use of onew-generation drug-eluting stents: a report from the nationwide Swedish Coronary Angiography and Angioplasty Registry (SCAAR)
Uppsala University.
Uppsala University.
Örebro University Hospital.
Umeå University Hospital.
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2012 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, no 5, 606-613 p.Article in journal (Refereed) Published
Abstract [en]

To compare the long-term outcome after percutaneous coronary intervention with onew-generation drug-eluting stents (n-DES) to oolder generation DES (o-DES), and bare-metal stents (BMS) in a real-world population. less thanbrgreater than less thanbrgreater thanWe evaluated 94 384 consecutive stent implantations (BMS, n 64 631; o-DES, n 19 202; n-DES, n 10 551) in Sweden from November 2006 to October 2010. All cases of definite stent thrombosis (ST) and restenosis were documented in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). Older generation DES were classified as: Cypher and Cypher Select (Cordis Corporation, Miami, FL, USA), Taxus Express and Taxus Libert (Boston Scientific Corporation), and Endeavor (Medtronic Inc.) and n-DES as: Endeavor Resolute (Medtronic Inc.), XienceV, Xience Prime (Abbott Laboratories) and Promus, Promus Element (Boston Scientific Corporation). The Cox regression analyses unadjusted and adjusted for clinical and angiographic covariates showed a statistically significant lower risk of restenosis in n-DES compared with BMS [adjusted hazard ratio (HR) 0.29; 95 confidence interval (CI): 0.250.33] and o-DES (HR 0.62; 95 CI: 0.530.72). A lower risk of definite ST was found in n-DES compared with BMS (HR 0.38; 95 CI: 0.280.52) and o-DES (HR, 0.57; 95 CI: 0.410.79). The risk of death was significantly lower in n-DES compared with o-DES (adjusted HR: 0.77; 95 CI: 0.630.95) and BMS (adjusted HR: 0.55; 95 CI: 0.460.67). less thanbrgreater than less thanbrgreater thanPercutaneous coronary intervention with n-DES is associated with a 38 lower risk of clinically meaningful restenosis, a 43 lower risk of definite ST, and a 23 lower risk of death compared with o-DES in this observational study from a large real-world population.

Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy B , 2012. Vol. 33, no 5, 606-613 p.
Keyword [en]
DES, Stent thrombosis
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-76192DOI: 10.1093/eurheartj/ehr479ISI: 000301004400017OAI: diva2:513207
Funding Agencies|Swedish Health Authorities||Swedish Heart and Lung Foundation||Terumo Inc.||Medtronic Inc.||Vascular Solutions||Available from: 2012-03-31 Created: 2012-03-30 Last updated: 2012-04-10

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