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Is a daily supplementation with 40 microgram vitamin D(3) sufficient? A randomised controlled trial
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Endocrinology and Gastroenterology UHL.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
2012 (English)In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 51, no 8, 939-945 p.Article in journal (Refereed) Published
Abstract [en]

Purpose  The effect of 40 μg (1,600 IU) per day of vitamin D3 on serum 25-hydroxyvitamin D (25(OH)D) and markers of bone and mineral metabolism was evaluated. Methods  This intervention study was designed as a double-blind randomised controlled trial. Forty-five community-dwelling subjects (32 females), age 55–84 years, at 58° North latitude were supplemented for 1 year with 40 μg vitamin D3 plus 1,000 mg calcium per day, or with 1,000 mg calcium per day for controls. Safety parameters and 25(OH)D, intact parathyroid hormone (PTH), ionized calcium, bone-specific alkaline phosphatase (BALP), and tartrate-resistant acid phosphatase isoform 5b (TRACP5b) were measured over the study period. Results  All subjects supplemented with vitamin D3 reached a 25(OH)D level above 50 nmol/L. Mean (SD) serum 25(OH)D increased from 50.4 (13.5) nmol/L to 84.2 (17.5) nmol/L, range 55.0–125.0 nmol/L in the vitamin D3 supplemented group and the corresponding levels for the control group were 47.3 (14.1) nmol/L and 45.7 (13.4) nmol/L, range 26.0–73.0 nmol/L. No serious adverse event was recorded and the highest 25(OH)D level reached, 125.0 nmol/L, is well below toxic levels. BALP and TRACP5b did not change significantly over the study period. Conclusions  This trial suggests that a daily supplementation with 40 μg vitamin D3 is sufficient to secure a 25(OH)D level of 50 nmol/L. No side effects were observed in the study group.

Place, publisher, year, edition, pages
Springer, 2012. Vol. 51, no 8, 939-945 p.
Keyword [en]
25-Hydroxyvitamin D – Vitamin D insufficiency – Hyperparathyroidism – Bone turnover – Calcium – Parathyroid hormone
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-76289DOI: 10.1007/s00394-011-0271-7ISI: 000310995200005PubMedID: 22086300OAI: diva2:513460

funding agencies|Meda AB, Solna, Sweden||

Available from: 2012-04-02 Created: 2012-04-02 Last updated: 2014-04-28

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Toss, GöranMagnusson, Per
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Internal MedicineFaculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHLClinical ChemistryDepartment of Clinical Chemistry
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European Journal of Nutrition
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