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Differences in prescription rates and odds ratios of antidepressant drugs in relation to individual hormonal contraceptives: A nationwide population-based study with age-specific analyses
Linköping University, Department of Medical and Health Sciences, General Practice. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in the West of Östergötland, Unit of Research and Development in Local Health Care, County of Östergötland.
Linköping University, Department of Medical and Health Sciences, Nursing Science. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Department of Medical and Health Sciences, Health and Society. Linköping University, Faculty of Arts and Sciences.
2012 (English)In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 17, no 2, 106-118 p.Article in journal (Refereed) Published
Abstract [en]

Objectives To examine, among young women, the association of individual hormonal contraceptives, within two broad groupings, with antidepressant therapy. less thanbrgreater than less thanbrgreater thanMethods In a nationwide register-based study, we examined the prescription rates of antidepressant drugs in relation to individual combined hormonal and progestin-only contraceptives among Swedish women aged 16-31 years (N = 917,993). Drug data were obtained from the Swedish Prescribed Drug Register for the period 1 July 2005-30 June 2008. Data on the total population of women aged 16-31 in 2008 were obtained from the Total Population Register of Statistics Sweden. The proportion of women using both hormonal contraception and antidepressants, and odds ratios (ORs) for antidepressant use for hormonal contraceptive users versus non-users, were calculated, the latter by logistic regression, for each formulation. less thanbrgreater than less thanbrgreater thanResults The highest antidepressant OR in all age groups, particularly in the 16-19 years age group, related to medroxyprogesterone-only, followed by etonogestrel-only, levonorgestrel-only and ethinylestradiol/norelgestromin formulations. Oral contraceptives containing ethinylestradiol combined with lynestrenol or drospirenone had considerably higher ORs than other pills. ORs significantly lower than 1 were observed when ethinylestradiol was combined with norethisterone, levonorgestrel or desogestrel. less thanbrgreater than less thanbrgreater thanConclusion The association between use of hormonal contraceptives and antidepressant drugs varies considerably within both the combined hormonal contraceptive and the progestin-only groups.

Place, publisher, year, edition, pages
Informa Healthcare , 2012. Vol. 17, no 2, 106-118 p.
Keyword [en]
Antidepressants, Combined hormonal contraceptives, Depression, Hormonal contraceptives, Progestin-only contraceptives, Mood, Registries
National Category
Social Sciences
Identifiers
URN: urn:nbn:se:liu:diva-76525DOI: 10.3109/13625187.2012.658925ISI: 000301493800003OAI: oai:DiVA.org:liu-76525DiVA: diva2:515144
Note
Funding Agencies|Swedish Society of Medicine Soderstrom-Konigska Foundation||Available from: 2012-04-12 Created: 2012-04-11 Last updated: 2017-12-07

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Lindberg, MalouFoldemo, AnniqaJosefsson, AnnWiréhn, Ann-Britt

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Lindberg, MalouFoldemo, AnniqaJosefsson, AnnWiréhn, Ann-Britt
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General PracticeFaculty of Health SciencesUnit of Research and Development in Local Health Care, County of ÖstergötlandNursing ScienceObstetrics and gynecologyDepartment of Gynecology and Obstetrics in LinköpingHealth and SocietyFaculty of Arts and Sciences
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European journal of contraception & reproductive health care
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