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A physiological Signal Transmission Model to be used for Specific Diagnosis of Cochlear Impairments
Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences. (Swedish institute for Disability Research, Linnaeus center, HEAD graduate school)
Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences. (Swedish institute for Disability Research, Linnaeus center)ORCID iD: 0000-0003-3350-8997
2011 (English)In: WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS: PROCEEDINGS OF THE 11TH INTERNATIONAL MECHANICS OF HEARING WORKSHOP / [ed] Shera, CA; Olson, ES, American Institute of Physics (AIP), 2011, Vol. 1403, 369-373 p.Conference paper, Published paper (Refereed)
Abstract [en]

Many of the sophisticated characteristics of human auditory system are attributed to cochlea. Also, most of patients with a hearing loss suffer from impairments that originate from cochlea (sensorineural). Despite this, today's clinical diagnostic methods do not probe the specific origins of such cochlear lesions. The aim of this research is to introduce a physiological signal transmission model to be clinically used as a tool for diagnosis of cochlear losses. This model enables simulation of different bio‐mechano‐electrical processes which occur in the auditory organ of Corti inside the cochlea. What makes this model different from many available computational models is its loyalty to physiology since the ultimate goal is to model each single physiological phenomenon. This includes passive BM vibration, outer hair cells' performances such as nonlinear mechanoelectrical transduction (MET), active amplifications by somatic motor, as well as vibration to neural conversion at the inner hair cells.

Place, publisher, year, edition, pages
American Institute of Physics (AIP), 2011. Vol. 1403, 369-373 p.
Keyword [en]
cochlear mechanics, auditory model, cochlear hearing loss, sensorineural, presbyacusis, stria vascularis
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-76599DOI: 10.1063/1.3658113ISI: 000301945200062OAI: oai:DiVA.org:liu-76599DiVA: diva2:515361
Conference
11th International Workshop on the Mechanics of Hearing, Williams Coll, Williamstown, MA, USA, JUL 16-22, 2011
Projects
HEAD hearing and deafness, IHV
Available from: 2012-04-12 Created: 2012-04-12 Last updated: 2014-10-08
In thesis
1. Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
Open this publication in new window or tab >>Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A hearing impairment is primarily diagnosed by measuring the hearing thresholds at a range of auditory frequencies (air-conduction audiometry). Although this clinical procedure is simple, affordable, reliable and fast, it does not offer differential information about origins of the hearing impairment. The main goal of this thesis is to quantitatively link specific cochlear pathologies to certain changes in the spectral and temporal characteristics of the auditory system. This can help better understand the underlying mechanisms associated with sensorineural hearing impairments, beyond what is shown in the audiogram. Here, an electromechanical signal-transmission model is devised in MATLAB where the parameters of the model convey biological interpretations of mammalian cochlear structures. The model is exploited to simulate the cell-level cochlear pathologies associated with two common types of sensorineural hearing impairments, 1: presbyacusis (age-related hearing impairment) and, 2: noise-induced hearing impairment. Furthermore, a clinical study, consisting of different psychoacoustic and physiological tests, was performed to trace and validate the model predictions in human. The results of the clinical tests were collated and compared with the model predictions, showing a reasonable agreement. In summary, the present model provides a biophysical foundation for simulating the effect of specific cellular lesions, due to different inner-ear diseases and external insults, on the entire cochlear mechanism and thereby on the whole auditory system. This is a multidisciplinary work in the sense that it connects the ‘biological processes’ with ‘acoustic modelling’ and ‘clinical audiology’ in a translational context.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 57 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1400Studies from the Swedish Institute for Disability Research, ISSN 1650-1128 ; 60
Keyword
Auditory modeling, cochlear mechanics, sensorineural hearing impairment, age-related hearing loss, noise-induced hearing loss, inner ear pathologies
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-105810 (URN)10.3384/diss.diva-105810 (DOI)978-91-7519-365-6 (ISBN)
Public defence
2014-04-28, Nils Holger salen, entrance 71, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Opponent
Supervisors
Available from: 2014-04-08 Created: 2014-04-08 Last updated: 2014-10-08Bibliographically approved

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Saremi, Amin GStenfelt, Stefan

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Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
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