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Local bisphosphonate release versus hydroxyapatite coating for stainless steel screw fixation in rat tibiae
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
University of Gothenburg.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
2012 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 23, no 3, 743-752 p.Article in journal (Refereed) Published
Abstract [en]

Implant fixation in bone can be improved by a coating that delivers bisphosphonates locally, or by a hydroxyapatite (HA) coating. In this study, we compared these different types of coatings. For mechanical testing, 30 rats were assigned into three groups, and similar screws were implanted bilaterally in the proximal tibiae. The rats received screws that were either uncoated, coated with nano-crystalline hydroxyapatite or coated with a bisphosphonate releasing protein matrix. After 4 weeks, one screw was subjected to pull-out testing, and the contra-lateral one to torsion testing. For morphology, 30 rats were assigned to similar treatment groups, but received only one screw each. Bisphosphonates enhanced the pull-out force by 41% (P = 0.02) compared to controls, HA increased the pull-out force although not significantly. Conversely, HA increased the maximal torque by 64% (P = 0.02). Morphometry showed higher bone volume around bisphosphonate screws in comparison to HA-coated screws (P andlt; 0.001) and controls (P andlt; 0.001). The results suggest that bisphosphonates improve fixation by increasing the amount of surrounding bone, whereas HA mainly improves bone to implant attachment.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2012. Vol. 23, no 3, 743-752 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-76616DOI: 10.1007/s10856-011-4539-5ISI: 000301639900014OAI: oai:DiVA.org:liu-76616DiVA: diva2:515449
Note
Funding Agencies|Swedish Research council|2009-6725|BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy at Sahlgrenska Academy, University of Gothenburg||Available from: 2012-04-13 Created: 2012-04-13 Last updated: 2017-12-07

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Agholme, FredrikAndersson, ThereseAspenberg, Per

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Agholme, FredrikAndersson, ThereseAspenberg, Per
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Orthopaedics and Sports MedicineFaculty of Health SciencesDepartment of Clinical and Experimental MedicineDepartment of Orthopaedics in Linköping
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