NF-kappa B p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients
2012 (English)In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 27, no 4, 447-452 p.Article in journal (Refereed) Published
The NF-kappa B transcription factor protein family has diverse cellular and biological functions, and posttranslational modification is important to regulate these functions. An important site of phosphorylation of NF-kappa B p65 subunit is at serine-536 (phospho-Ser536-p65), and this phosphorylation is involved in regulation of transcriptional activity, nuclear localization, and protein stability. less thanbrgreater than less thanbrgreater thanIn this study, we investigated expression of phospho-Ser536-p65 in colorectal cancers and its relationships with clinicopathological factors. The expression of phospho-Ser536-p65 was examined by immunohistochemistry in 203 primary colorectal cancers, 156 normal mucosa specimens, and 18 metastases in the lymph nodes. less thanbrgreater than less thanbrgreater thanThe expression of phospho-Ser536-p65 increased from normal mucosa to primary tumor (p andlt; 0.0001). Further, the increased expression of phospho-Ser536-p65 in the cytoplasm of the primary tumors correlated with worse survival of the patients independently of gender, age, tumor location, stage, and differentiation (p = 0.04; hazard ratio, 1.89; 95% CI 1.03-3.47). less thanbrgreater than less thanbrgreater thanThe NF-kappa B p65 subunit phosphorylated at serine-536 is an independent prognostic factor in colorectal cancer patients.
Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2012. Vol. 27, no 4, 447-452 p.
NF-kappa B, Survival, Colorectal cancer, Immunohistochemistry
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-76610DOI: 10.1007/s00384-011-1356-8ISI: 000301777100004OAI: oai:DiVA.org:liu-76610DiVA: diva2:515454
Funding Agencies|Swedish Cancer Foundation||Swedish Research Council||Health Research Council in the Southeast of Sweden||2012-04-132012-04-132012-06-29