Insulin signaling - mathematical modeling comes of age
2012 (English)In: Trends in endocrinology and metabolism, ISSN 1043-2760, E-ISSN 1879-3061, Vol. 23, no 3, 107-115 p.Article, review/survey (Refereed) Published
Signaling pathways that only a few years ago appeared simple and understandable, albeit far from complete, have evolved into very complex multi-layered networks of cellular control mechanisms, which in turn are integrated in a similarly complex whole-body level of control mechanisms. This complexity sets limits for classical biochemical reasoning, such that a correct and complete analysis of experimental data while taking the full complexity into account is not possible. In this Opinion we propose that mathematical modeling can be used as a tool in insulin signaling research, and we demonstrate how recent developments in modeling - and the integration of modeling in the experimental process - provide new possibilities to approach and decipher complex biological systems more efficiently.
Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 23, no 3, 107-115 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-76962DOI: 10.1016/j.tem.2011.12.007ISI: 000302444900002OAI: oai:DiVA.org:liu-76962DiVA: diva2:523992
Funding Agencies|European Commission Network of Excellence Biosim||Novo Nordisk Foundation||Swedish Diabetes Association||Swedish Research Council||Lions||2012-04-272012-04-272012-04-27