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Preparation of amyloidlike fibrils containing magnetic iron oxide nanoparticles: Effect of protein aggregation on proton relaxivity
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
2012 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 419, no 4, 682-686 p.Article in journal (Refereed) Published
Abstract [en]

A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid material is heated in aqueous acid, the insulin/nanoparticle hybrid material self assembles to form amyloid-like fibrils incorporating the magnetic nanoparticles. This results in magnetically labeled amyloid-like fibrils which has been characterized by Transmission Electron Microscopy (TEM) and electron tomography. The influence of the aggregation process on proton relaxivity is investigated. The prepared materials have potential uses in a range of bio-imaging applications.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 419, no 4, 682-686 p.
Keyword [en]
Amyloid fibrils, Magnetic nanoparticles, Electron tomography, Self-assembly, Proton relaxation
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-76954DOI: 10.1016/j.bbrc.2012.02.077ISI: 000302335800016OAI: oai:DiVA.org:liu-76954DiVA: diva2:524357
Note

Funding Agencies|Swedish Research Council (VR)||VINNOVA||Carl Trygger Foundation|10:388|Swedish Royal Academy of Sciences (INA)||Lars Hiertas foundation||

Available from: 2012-05-02 Created: 2012-04-27 Last updated: 2017-12-07

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Andersson, ViktorSkoglund, CarolineUvdal, KajsaSolin, Niclas

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Andersson, ViktorSkoglund, CarolineUvdal, KajsaSolin, Niclas
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Biomolecular and Organic ElectronicsThe Institute of TechnologyMolecular Surface Physics and Nano ScienceFaculty of Science & Engineering
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Engineering and Technology

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