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DNA detection with a water-gated organic field-effect transistor
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology. (Organic Electronics)
Université Paris Diderot, France.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology. (Organic Electronics)ORCID iD: 0000-0001-5154-0291
Université Paris Diderot, France.
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2012 (English)In: Organic electronics, ISSN 1566-1199, E-ISSN 1878-5530, Vol. 13, no 1, 1-6 p.Article in journal (Refereed) Published
Abstract [en]

A DNA sensor based on a water-gated organic field-effect transistor is described. The semiconductor is poly [3-(5-carboxypentyl)thiophene-2,5-diyl] onto which DNA probes are covalently grafted via NHS/EDC chemistry. Clear changes in the output characteristic of the device are observed upon DNA immobilization and after DNA hybridization. Experimental data point out the importance of the electrolyte Debye length that can screen negative DNA charges and impede transduction. For this reason, deionized water was used in order to increase the Debye length up to several hundreds of nanometers. In this case, a decrease in the off current was observed upon hybridization, whereas no significant change occurred when using saline solutions.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 13, no 1, 1-6 p.
Keyword [en]
Electrolytic-gated organic field effect transistor (EGOFET);DNA sensor; Organic Transistor; Reagentless detection
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-77002DOI: 10.1016/j.orgel.2011.09.025ISI: 000298152100001OAI: oai:DiVA.org:liu-77002DiVA: diva2:524366
Available from: 2012-05-02 Created: 2012-05-02 Last updated: 2017-12-07

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Kergoat, LoigBerggren, Magnus

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