Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein
2012 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 32, no 4, 1443-1448 p.Article in journal (Refereed) Published
Aim: The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP. Materials and Methods: Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables. Results: The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04). Conclusion: The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.
Place, publisher, year, edition, pages
International Institute of Anticancer Research (IIAR) , 2012. Vol. 32, no 4, 1443-1448 p.
Pseudomyxoma peritonei, histopathology, PINCH, protein expression, cytokeratin 7, Ki-67
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-76938ISI: 000302492600043OAI: oai:DiVA.org:liu-76938DiVA: diva2:524587
Funding Agencies|Lions Cancer Research Foundation||Uppsala University Hospital||Uppsala University Hospital for Clinical research (Sadd-ALF), Uppsala Sweden||2012-05-032012-04-272012-05-03