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Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design
Helsingborg Hospital.
Copenhagen University Hospital.
University of London St Georges Hospital.
Sahlgrens University Hospital.
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2012 (English)In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 163, no 4, 541-548 p.Article in journal (Refereed) Published
Abstract [en]

Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32 degrees C to 34 degrees C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known. less thanbrgreater than less thanbrgreater thanMethods The TTM trial is an investigator-initiated, international, randomized, parallel-group, and assessor-blinded clinical trial designed to enroll at least 850 adult, unconscious patients resuscitated after out-of-hospital cardiac arrest of a presumed cardiac cause. The patients will be randomized to a target temperature management of either 33 degrees C or 36 degrees C after return of spontaneous circulation. In both groups, the intervention will last 36 hours. The primary outcome is all-cause mortality at maximal follow-up. The main secondary outcomes are the composite outcome of all-cause mortality and poor neurologic function (cerebral performance categories 3 and 4) at hospital discharge and at 180 days, cognitive status and quality of life at 180 days, assessment of safety and harm. less thanbrgreater than less thanbrgreater thanDiscussion The TTM trial will investigate potential benefit and harm of 2 target temperature strategies, both avoiding hyperthermia in a large proportion of the out-of-hospital cardiac arrest population.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 163, no 4, 541-548 p.
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-77540DOI: 10.1016/j.ahj.2012.01.013ISI: 000303106800013OAI: diva2:528355

Funding Agencies|Swedish Heart and Lung Foundation, Sweden||AFA Insurance Foundation, Sweden||Swedish National Health System (ALF), Sweden||County Council of Skane, Sweden||Stig and Ragna Gorthon Foundation, Sweden||Thure Carlsson Foundation, Sweden||Segerfalk Foundation, Sweden||Gyllenstierna-Krapperup Foundation, Sweden||

Available from: 2012-05-25 Created: 2012-05-22 Last updated: 2014-01-16Bibliographically approved

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Wyon, Nicholas
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Department of Anaesthesiology and Intensive Care in NorrköpingDepartment of Anaesthesiology and Intensive Care in LinköpingFaculty of Health Sciences
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