liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Dietary Mustard Seeds (Sinapis alba Linn) Suppress 1,2-Dimethylhydrazine-Induced Immuno-Imbalance and Colonic Carcinogenesis in Rats
So Medical University.
So Medical University.
So Medical University.
So Medical University.
Show others and affiliations
2012 (English)In: Nutrition and Cancer, ISSN 0163-5581, E-ISSN 1532-7914, Vol. 64, no 3, 464-472 p.Article in journal (Refereed) Published
Abstract [en]

In a Wistar rat model, prolonged supplementation of mustard seed (MS) to the diet significantly ameliorates the induction of colorectal carcinomas by 1,2-dimethylhydrazine (DMH). The expression of the splenocyte major histocompatibility complex class I (MHCI) was found significantly enhanced, whereas that of the major histocompatibility complex class II (MHCII) was significantly decreased. Compared to that of control animals, the proportion of spleenic B- and dendritic cells (DC) was amplified in the MS group. The expressions of MHCI, as well as that of MHCII, were increased in DC cells; whereas in B cells, MHCI expression was augmented but that of MHCII moderately decreased. The percentages of CD8+CD28+ and CD4+CD28+ cells were increased in the MS group, while the CD4+CD25+Foxp3+ subset was depressed. Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2,IL12p70,IL21, TNF-alpha, and interferon-gamma. In the SW480 colon adenocarcinoma cell-line, the cytotoxicity of spleenic T-cells from MS-fed animals was significantly increased. In the DMH-exposed rats, the expression of perforin in the spleenic T-cells was dramatically decreased, whereas MS abolished this depression. In summary, dietary MS suppresses DMH-induced immuno-imbalance as well as colon carcinogenesis in rats.

Place, publisher, year, edition, pages
Taylor and Francis (Routledge): STM, Behavioural Science and Public Health Titles / Taylor and Francis (Routledge) , 2012. Vol. 64, no 3, 464-472 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-77874DOI: 10.1080/01635581.2012.658948ISI: 000303702600012OAI: diva2:529684
Funding Agencies|National Natural Science Foundation of China|81071549|Guangdong Natural Science Foundation|9151040701000025|Guangdong Science and Technology Foundation|2010B060900054|Foundation for Introduction of Innovative R & D Team in Guangdong Province||Nanfang Hospital Foundation|2009B011|Guangdong Talent Person Import Foundation||Southern Medical University Talent Person Import Foundation||China Chunhui Plan||Available from: 2012-05-31 Created: 2012-05-31 Last updated: 2012-05-31

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Brunk, Ulf
By organisation
PharmacologyFaculty of Health Sciences
In the same journal
Nutrition and Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 37 hits
ReferencesLink to record
Permanent link

Direct link