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Is the link between anatomical macrostructure and function equally strong at all cognitive levels of processing?
Baycrest Centre for Geriatric Care.
Medical Research Council Cognition and Brain Sciences Unit.
Queen’s University.
University College London.
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2012 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 22, no 7, 1593-1603 p.Article in journal (Refereed) Published
Abstract [en]

Whereas low-level sensory processes can be linked to macroanatomy with great confidence, the degree to which high-level cognitive                     processes map onto anatomy is less clear. If function respects anatomy, more accurate intersubject anatomical registration                     should result in better functional alignment. Here, we use auditory functional magnetic resonance imaging and compare the                     effectiveness of affine and nonlinear registration methods for aligning anatomy and functional activation across subjects.                     Anatomical alignment was measured using normalized cross-correlation within functionally defined regions of interest. Functional                     overlap was assessed using t-statistics from the group analyses and the degree to which group statistics predict high and consistent signal change in                     individual data sets. In regions related to early stages of auditory processing, nonlinear registration resulted in more accurate                     anatomical registration and stronger functional overlap among subjects compared with affine. In frontal and temporal areas                     reflecting high-level processing of linguistic meaning, nonlinear registration also improved the accuracy of anatomical registration.                     However, functional overlap across subjects was not enhanced in these regions. Therefore, functional organization, relative                     to anatomy, is more variable in the frontal and temporal areas supporting meaning-based processes than in areas devoted to                     sensory/perceptual auditory processing. This demonstrates for the first time that functional variability increases systematically                     between regions supporting lower and higher cognitive processes.                 

Place, publisher, year, edition, pages
Oxford University Press, 2012. Vol. 22, no 7, 1593-1603 p.
National Category
Psychology (excluding Applied Psychology)
URN: urn:nbn:se:liu:diva-78194DOI: 10.1093/cercor/bhr205ISI: 000305610700012OAI: diva2:531673
Available from: 2012-06-07 Created: 2012-06-07 Last updated: 2015-04-16

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Johnsrude, Ingrid
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Department of Behavioural Sciences and LearningFaculty of Arts and Sciences
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Cerebral Cortex
Psychology (excluding Applied Psychology)

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