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Monozygotic twins discordant for intermittent allergic rhinitis differ in mRNA and protein levels
University of Gothenburg.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Padua Gen University Hospital.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
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2012 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 67, no 6, 831-833 p.Article in journal (Refereed) Published
Abstract [en]

Monozygotic (MZ) twins discordant for complex diseases may help to find disease mechanisms that are not due to genetic variants. Intermittent allergic rhinitis (IAR) is an optimal disease model because it occurs at defined time points each year, owing to known external antigens. We hypothesized that MZ twins discordant for IAR could help to find gene expression differences that are not dependent on genetic variants. We collected blood outside of the season from MZ twins discordant for IAR, challenged their peripheral blood mononuclear cells (PBMC) with pollen allergen in vitro, collected supernatants and isolated CD4+ T cells. We identified disease-relevant mRNAs and proteins that differed between the discordant MZ twins. By contrast, no differences in microRNA expression were found. Our results indicate that MZ twins discordant for IAR is an optimal model to identify disease mechanisms that are not due to genetic variants.

Place, publisher, year, edition, pages
John Wiley and Sons , 2012. Vol. 67, no 6, 831-833 p.
Keyword [en]
allergens, CD4+T cells, clinical immunology, discordant twins
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-78268DOI: 10.1111/j.1398-9995.2012.02828.xISI: 000303854900017OAI: oai:DiVA.org:liu-78268DiVA: diva2:531845
Note

Funding Agencies|European Commission|223367|Swedish Research Council||

Available from: 2012-06-08 Created: 2012-06-08 Last updated: 2017-12-07Bibliographically approved

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Barrenäs, FredrikGustafsson, MikaWang, HuiBenson, Mikael

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Barrenäs, FredrikGustafsson, MikaWang, HuiBenson, Mikael
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CiteExportLink to record
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