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Two-dimensional gel electrophoresis and mass spectrometry in studies of nanoparticle-protein interactions
Linköping University, Department of Clinical and Experimental Medicine, Work and Environmental Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Occupational and Environmental Medicine Center.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Medical and Health Sciences, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
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2012 (English)In: Gel electrophoresis-Advanced Techniques / [ed] Sameh Magdeldin, Rijeka, Croatia: In Tech , 2012, 1-32 p.Chapter in book (Other academic)
Abstract [en]

Over the years a number of epidemiological studies have shown that PM from combustion sources such as motor vehicles contributes to respiratory and cardiovascular morbidity and mortality.Especially so do the ultra-fine particles (UFPs) with a diameter less than 0.1 micrometer.UFPs from combustion engines are capable to translocate over the alveolar–capillary barrier.  When nano-sized PM (nanoparticles, NP), which are small enough to enter the blood stream, do so they are likely to interact with plasma proteins and this protein-NP interaction will probably affect the fate of and the effects caused by the NPs in the human body. Here, by using a proteomic approach, we present results showing that several proteins indeed are associated to NPs that have in vitro been introduced to human blood plasma.

Place, publisher, year, edition, pages
Rijeka, Croatia: In Tech , 2012. 1-32 p.
Keyword [en]
Proteins, Nanoparticles, Gelelectrophoresis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-78397DOI: 10.5772/38085ISBN: 978-953-51-0457-5 (print)OAI: oai:DiVA.org:liu-78397DiVA: diva2:532362
Available from: 2012-06-11 Created: 2012-06-11 Last updated: 2015-05-29Bibliographically approved

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Publisher's full textfind book at a swedish libraryhitta boken i ett svenskt biblioteklink to artikle

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Karlsson, HelenLjunggren, StefanAhrén, MariaGhafouri, BijarUvdal, KajsaLindahl, MatsLjungman, Anders

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Karlsson, HelenLjunggren, StefanAhrén, MariaGhafouri, BijarUvdal, KajsaLindahl, MatsLjungman, Anders
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Work and Environmental ScienceFaculty of Health SciencesOccupational and Environmental Medicine CenterDepartment of Clinical and Experimental MedicineMolecular Surface Physics and Nano ScienceFaculty of Science & EngineeringRehabilitation MedicinePain and Rehabilitation Center
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