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Does patency after a vein collar and PTFE-bypass depend on sex and age? Re-analysis of a randomised trial
Linköping University, Department of Medical and Health Sciences, Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Thoracic and Vascular Surgery in Östergötland.
2012 (English)In: International Journal of Angiology, ISSN 0392-9590, Vol. 31, no 2, 156-162 p.Article in journal (Refereed) Published
Abstract [en]

Aim. Randomized studies evaluating the effect of a vein collar at the distal anastomosis of PTFE-grafts show conflicting results. The study of the Joint Vascular Research Group (JVRG) of UK found improved primary patency while the Scandinavian Miller Collar Study (SCAMICOS) found neither any effect on patency nor on limb salvage after bypass to below-knee arteries. However, the Scandinavian patients were a decade older and predominately female compared to the British patients. Can this explain the conflicting result? less thanbrgreater than less thanbrgreater thanMethods: Primary patency with respect to sex, age and the use of vein collar were re-analysed in 345 patients from SCAMICOS with Kaplan-Meier life-table technique, log-rank test and Cox proportional hazards regression to evaluate any interaction between sex or age and the effect of a vein collar on the primary patency rate. less thanbrgreater than less thanbrgreater thanResults. Females had better patency than males (log-rank test, chi(2)=9.4, df=1, P=0.002) but age had no influence on patency (log-rank test, chi(2)=3.3, df=3, P=0.35). However, 47% of the males compared to 23% of the females were smokers (P=0.00002). No interaction effect between sex and vein collar (P-value=0.224) or age and vein collar (P-value=0527) was established. less thanbrgreater than less thanbrgreater thanConclusion. The difference between the two randomised vein collar studies are unlikely to depend on the disparity in sex and age of the study populations.

Place, publisher, year, edition, pages
Edizione Minerva Medica , 2012. Vol. 31, no 2, 156-162 p.
Keyword [en]
Polytetrafluoroethylene, Poplitel artery, Tibial arteries
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-79111ISI: 000304743000009OAI: diva2:538243
Funding Agencies|IMPRA, Sweden||W. L. Gore & Associates, Sweden||Available from: 2012-06-29 Created: 2012-06-29 Last updated: 2012-06-29

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Lundgren, Fredrik
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PhysiologyFaculty of Health SciencesDepartment of Thoracic and Vascular Surgery in Östergötland
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