Inhibiting host-pathogen interactions using membrane-based nanostructures
2012 (English)In: Trends in Biotechnology, ISSN 0167-7799, E-ISSN 1879-3096, Vol. 30, no 6, 323-330 p.Article, review/survey (Refereed) Published
Virulent strains of bacteria and viruses recognize host cells by their plasma membrane receptors and often exploit the native translocation machinery to invade the cell. A promising therapeutic concept for early interruption of pathogen infection is to subvert this pathogenic trickery using exogenously introduced decoys that present high-affinity mimics of cellular receptors. This review highlights emerging applications of molecularly engineered lipid-bilayer-based nanostructures, namely (i) functionalized liposomes, (ii) supported colloidal bilayers or protocells and (Hi) reconstituted lipoproteins, which display functional cellular receptors in optimized conformational and aggregative states. These decoys outcompete host cell receptors by preferentially binding to and neutralizing virulence factors of both bacteria and viruses, thereby promising a new approach to antipathogenic therapy.
Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 30, no 6, 323-330 p.
host-pathogen interaction, antiviral, antipathogenic decoys, membrane receptors, binding affinity, reconstituted (synthetic) lipoprotein, membrane nanostructures
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-79094DOI: 10.1016/j.tibtech.2012.03.002ISI: 000304851700004OAI: oai:DiVA.org:liu-79094DiVA: diva2:538263
Funding Agencies|US Department of Energy, Office of Basic Energy Science through Division of Materials Science and Engineering|DE FG02-04ER46173|NIH road map initiative through the Nanomedicine Development Center (National Center for the Design of Biomimetic Nanoconductors)|PHS 2 PN2 EY016570B|National Science Foundation||Linkoping University||2012-06-292012-06-292012-07-24