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M-mode magnetic resonance imaging: a new modality for assessing cardiac function
Linköping University, Department of Medicine and Care, Clinical Physiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences.
Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
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1995 (English)In: Clinical Physiology, ISSN 0144-5979, E-ISSN 1365-2281, Vol. 15, no 4, 397-407 p.Article in journal (Refereed) Published
Abstract [en]

Magnetic resonance imaging (MRI) studies of the heart have been used for some years, but there are few tools available to quantify cardiac motion. A method has been developed that creates an M-mode MRI image, analogous to the one used in echocardiography, to display motion along a line as a function of time. The M-mode image is created from MRI images acquired with an ordinary gradient echo cine sequence. In a cinematographic display of the images, a cursor line can be positioned in order to determine the orientation of the measurement. A resampling algorithm then calculates the appearance of the M-mode image along the cursor line. The MRI method has been compared to echocardiographic M-mode in a phantom study and by measuring mitral and tricuspid annulus motion in 20 normal subjects. The phantom study showed no significant differences between MRI and echocardiographic M-mode measurements (difference mm). The annulus motion exhibits a similar pattern using both methods and the measured amplitudes are in close agreement. M-mode MRI provides similar information to echocardiography, but the cursor line can be placed arbitrarily within the image plane and the method is thus not limited to certain acoustic windows. This makes M-mode MRI a promising technique for assessing cardiac motion.

Place, publisher, year, edition, pages
1995. Vol. 15, no 4, 397-407 p.
Keyword [en]
cardiac motion, heart, image processing, MRI, M-mode
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-79469DOI: 10.1111/j.1475-097X.1995.tb00529.xOAI: oai:DiVA.org:liu-79469DiVA: diva2:542568
Available from: 2012-08-02 Created: 2012-08-02 Last updated: 2017-12-07Bibliographically approved
In thesis
1. Annular Motion: Assessment of Cardiac Function using Echocardiography and Magnetic Resonance Imaging
Open this publication in new window or tab >>Annular Motion: Assessment of Cardiac Function using Echocardiography and Magnetic Resonance Imaging
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis concentrates on the assessment of cardiac function, both systolic and diastolic using variables originating from the longitudinal motion of the heart using both established and novel non-invasive imaging techniques. We developed a new magnetic resonance imaging (MRI) technique that creates an M-mode MRI image, analogous to the one used in echocardiography and enables quantitative assessment of cardiac motion. The MRI M-mode method was compared with M-mode echocardiography in a phantom study, by measuring mitral and tricuspid annular motion in 20 normal subjects, and in a study of right ventricular function in 17 patients after coronary artery bypass surgery. The agreement between M-mode MRI and Mmode echocardiography was good. However, the amplitudes were somewhat higher measured by MRI, probably because of less angle error in the MRI calculation, furthermore the lower resolution in the MRI image may have contributed.

Pulsed tissue Doppler, a recently developed Doppler modality that gives the possibility of recording instantaneous annular /or myocardial velocities on-line, was used to obtain reference values of mitral and tricuspid annular motion in 27 normal subjects of different ages. Diastolic left ventricular function was assessed in 15 patients with systemic hypertension and in 10 patients with moderate to severe aortic stenosis. Furthermore, pulsed tissue Doppler was used in the evaluation of right and left ventricular function in 15 patients with arrhythmogenic right ventricular cardiomyopathy (ARVC).

The mitral and tricuspid annular velocity pattern in normal subjects is characterised by three major components: asystolic (SA) velocity, an early (EA) diastolic velocity, and a late (AA) diastolic velocity. In normal young subjects, the EA-peak velocity was highest; with increasing age, the EA-peak velocity decreases and the AA-peak velocity increases, with similar changes in both the mitral and tricuspid annular velocity pattern. In patients with left ventricular hypertrophy the EA/AA-ratio was significantly decreased compared with age- match normal subjects. Comparing ARVC patients with normal subjects the tricuspid annular EA-peak velocity was significantly decreased as well as the lateral SA-peak velocity. Our result indicates that abnormal diastolic tricuspid annular velocity pattern may be an early sign of right ventricular myocardial dysfunction in patients with ARVC. The septal mitral annular SA-peak velocity was significantly decreased in ARVC patients compared to the controls. This in accordance with subjective analysis of echocardiographic wall motion and T1-201 SPECT that showed left ventricular abnormalities in 93% of the patients predominantly located in the anteroseptal and posteroseptal segments.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2000. 56 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 620
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27516 (URN)12172 (Local ID)91-7219-577-0 (ISBN)12172 (Archive number)12172 (OAI)
Public defence
2000-03-24, Berzeliussalen, Universitetssjukhuset, Linköping, 09:00 (Swedish)
Opponent
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2012-08-02Bibliographically approved
2. Multidimensional magnetic resonance imaging: new methods for analysis of cardiovascular dynamics
Open this publication in new window or tab >>Multidimensional magnetic resonance imaging: new methods for analysis of cardiovascular dynamics
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cardiovascular flow and motion occur in three-dimensional (3D) space and vary dynamically over the cardiac cycle. The description of these complicated patterns using non-invasive imaging requires new tools for data acquisition, processing and visualization. In this thesis, a number of techniques are presented, all of which aim at improving the description of multidimensional cardiovascular flow and motion.

For the study of cardiac motion, a new M-mode method was developed that uses time-resolved image data to retrospectively calculate an M-mode image along an arbitrary line. This reduces the dimensionality of the acquired image data to one dimension plus time, which facilitates the analysis of the motion of cardiac structures. In order to describe flow patterns within the heart and great vessels, phase contrast magnetic resonance imaging (MRI) can be used to accurately measure velocities. Existing techniques for the acquisition of phase contrast data were extended in order to acquire time-resolved 3D image data that contain information about all three velocity components in each voxel. A number of possible approaches for reducing the scan time required were applied. Reducing the scan time in MRI often results in images with a poor signal-to-noise ratio (SNR). Image processing techniques were therefore investigated that utilize adaptive filtering in order to reduce the noise level, while still preserving the details of small structures. Once multidimensional image data are acquired, there is an immediate need to visualize the data in a comprehensible way. Particle trace visualization of velocity vector data was applied in order to study flow patterns in the human heart. Using these methods, completely new insights into the patterns of blood flow within the left atrium were achieved. This and future applications are made possible by the powerful combination of massive multidimensional data sets and tools developed specifically for the complicated conditions of cardiovascular flow.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2003. 74 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 807
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-29438 (URN)14784 (Local ID)91-7373-616-3 (ISBN)14784 (Archive number)14784 (OAI)
Public defence
2003-04-29, Föreläsningssal Conrad, Universitetssjukhuset, Linköping, 13:15 (Swedish)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-01-04

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Wigström, LarsLindström, LenaSjöqvist, LarsWranne, Bengt

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