Neuropathy in diabetic BB/Wor rats treated with insulin implants
1998 (English)In: Acta Neuropathologica, ISSN 0001-6322, E-ISSN 1432-0533, Vol. 96, no 2, 144-150 p.Article in journal (Refereed) Published
To elucidate the pathophysiology of diabetic neuropathy many workers have examined nerve specimens from diabetic rats. While most workers found that animals with high blood glucose levels develop neuropathy, some researchers report that the peripheral nerves are normal in hyperglycaemic rats. Hypoglycaemia may also cause neuropathy. Some workers suggest that neuropathy is linked to fluctuations of the blood glucose level. In the present study we examine plantar nerves of diabetic BB/ Wor rats maintained on an eu-/hyperglycaemic or an eu-/ hypoglycaemic regime with insulin implants. Treatment with implants worked well. Light microscopic examination of nerve fibres in non-diabetic control rats and in eu-/ hyperglycaemic diabetic rats showed a normal picture. Preparations from eu-/hypoglycemic rats showed irregular myelin sheaths and signs of Wallerian degeneration. The lengths and diameters of the largest internodes were significantly subnormal. We conclude, that periodic moderate hypoglycaemia, but not periodic moderate hyperglycaemia, elicits neuropathy in diabetic BB/Wor rats treated with insulin implants.
Place, publisher, year, edition, pages
1998. Vol. 96, no 2, 144-150 p.
Neuropathy, Hypoglycaemia, Hyperglycaemia, Insulin, BB/Wor rat
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-79476DOI: 10.1007/s004010050874OAI: oai:DiVA.org:liu-79476DiVA: diva2:542747