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Functional evaluation of regenerated and misrouted axons to glabrous and hairy skin of the rat hind foot after sciatic neurotomy and suture
Linköping University, Department of Biomedicine and Surgery, Plastic Surgery, Hand Surgery and Burns. Linköping University, Department of Biomedicine and Surgery, Cell biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedicine and Surgery, Plastic Surgery, Hand Surgery and Burns. Linköping University, Faculty of Health Sciences.
1995 (English)In: Experimental Neurology, ISSN 0014-4886, E-ISSN 1090-2430, Vol. 132, no 1, 99-104 p.Article in journal (Refereed) Published
Abstract [en]

The function of misrouted regenerated polymodal nociceptor C-fibers and low-threshold mechanoreceptive axons in the lateral plantar nerve (LPN) and in the foot branch of the superficial peroneal nerve (fSPN) was evaluated 3 months after unilateral sciatic neurotomy and suture. Two weeks before evaluation the tibial fascicle (or the peroneal fascicle) above the neurotomy was cut and tied off. In this way only functional regeneration of misrouted axons was tested in the LPN (or the fSPN). In regenerated animals the glabrous skin area had no functional fSPN-related low-threshold mechanoreceptive axons. However, the hairy fSPN skin area showed function of misrouted LPN-related low-threshold mechanoreceptive axons. In both the glabrous skin domain innervated by the LPN and the hairy skin area supplied by the fSPN, functional regeneration of misrouted polymodal nociceptor C-fibers was found. We conclude that functional regeneration of misrouted axons related to polymodal nociceptive units and low-threshold mechanoreceptive units is more efficient in hairy skin of the rat foot whereas only misrouted polymodal nociceptor C-fibers recover function in glabrous skin.

Place, publisher, year, edition, pages
1995. Vol. 132, no 1, 99-104 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-79479DOI: 10.1016/0014-4886(95)90063-2OAI: oai:DiVA.org:liu-79479DiVA: diva2:542784
Available from: 2012-08-03 Created: 2012-08-03 Last updated: 2017-12-07Bibliographically approved
In thesis
1. Peripheral and central effects of nerve regeneration: Experimental and clinical studies
Open this publication in new window or tab >>Peripheral and central effects of nerve regeneration: Experimental and clinical studies
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A nerve injury in the hand often results in profound abnmmalities in sensory perception despite careful alignment and microsurgical repair in order to facilitate accurate nerve regeneration. The present experimental and clinical studies were undertaken in an attempt to functionally evaluate peripheral and central effects of nerve regeneration.

In the experimental studies the rat foot was used as a model for the human hand. Three months after neurotomy and repair a flUlctional evaluation was performed of regenerated and misrouted polymodal nociceptor C-fibers and low-threshold mechanoreceptive axons by mechanical stimulation on the foot and electrical recordings proximal to the lesion and by Evans blue albumin extravasation.

It was found that 1) functional regeneration of misrouted axons related to polymodal nociceptive units and low-threshold mechanoreceptive units is more efficient in hairy skin of the rat foot whereas only misrouted polymodal nociceptor C-fibers recover function in glabrous skin, 2) following epineural suture and repair with a silicone tube after sciatic neurotomy there is similar effect on the regeneration of polymodal C-fibers after three months, and 3) functional regeneration of C-fibers is more successful in 3-month-old than in new-born rats.

In the clinical studies the functional effects of median nerve injury and regeneration were evaluated by two-point discrimination test, electroneurography, somatosensory evoked potentials and functional magnetic resonance imaging (IMRI). A method oftMRI during tactile stimulation was developed, and the normal cortical activation during stimulation was studied in 12 healthy volunteers.

The effects of nerve injury were studied in 6 injured adult men 15-55 months after median nerve injury and repair. It was found that 1) the 2-point discrimination was > 15 mm, 2) the nerve conduction velocity and signal amplitude were decreased in the severed nerve segment, but the cortical evoked response was normal at nerve stimulation proximal to the lesion, 3) tactile stimulation of the glabrous skin of the hand in healthy volunteers caused bilateral cortical activation (fMRI) in the primary somatosensory cortex, 4) a loss of sensory discrimination in the hand after median nerve injury was associated with a normal or even elevated activation (fMRI) in the somatosensory cortex during tactile stimulation of the digit IT-m.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2000. 35 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 617
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28041 (URN)12802 (Local ID)91-7219-574-6 (ISBN)12802 (Archive number)12802 (OAI)
Public defence
2000-03-03, Berzeliussalen, Universitetssjukhuset, Linköping, 09:15 (Swedish)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2012-08-03Bibliographically approved

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